大神　信孝　OHGAMI Nobutaka

プロフィール

職名	講師
所属	生命健康科学部 生命医科学科 大学院 生命健康科学研究科 生命医科学専攻 臨床検査技術教育・実習センター 工学部共通教育科 （教養課題教育〈科学技術リテラシー〉担当）
最終学歴	熊本大学大学院・薬学研究科
学位	薬学博士（熊本大学）
資格	薬剤師
所属学会・役職	日本衛生学会 日本色素細胞学会 日本薬学会 American Heart Association
専門分野	衛生化学、環境衛生学
研究テーマ	遺伝子改変マウスを用いた生理機能の解析、細胞内コレステロール代謝
授業科目	環境衛生学
共同研究キーワード	神経変性、コレステロール

学術論文、評論

Ohgami, N., Kondo, T., Kato, M. (2011) Effects of light smoking on extra-high-frequency auditory thresholds in young adults. Toxicol Ind Health, 27(2):143-147.

Kato M, Kumasaka MY, Takeda K, Hossain K, Iida M, Goto Y, Ohgami N. (2010) l-cysteine as a regulator for arsenic-mediated cancer-promoting and anti-cancer effects. Toxicol In Vitro, in press.

Ohgami N, Ida M, Shimotake T, Sakashita N, Sone M, Nakashima T, Tabuchi K, Hoshino T, Shimada A, Tsuzuki T, Yamamoto M, Sobue G, Jijiwa M, Asai N, Hara A, Takahashi M, Kato M. c-Ret-mediated hearing loss in mice with Hirschsprung disease. (2010) Proc Natl Acad Sci USA, 107(29):13051-13056.

Kato M, Takeda K, Hossain K, Thang ND, Yu Kaneko Y, Mayuko Kumasaka YM, Yamanoshita O, Uemura N, Takahashi M, Ohgami N, Kawamoto Y. A redox-linked novel pathway for arsenic-mediated RET tyrosine kinase activation. (2010) J Cell Biochem. 110(2):399-407.

Chi X, Michos O, Shakya R, Riccio P, Enomoto H, Licht JD, Asai N, Takahashi M, Ohgami N, Kato M, Mendelsohn C, Costantini F. Ret-dependent cell rearrangements in the Wolffian duct epithelium initiate ureteric bud morphogenesis. (2009) Dev Cell. 17, 199-209

Yajima I, Kumasaka M, Thang ND, Yanagishita T, Ohgami N, Kallenberg D, Naito Y, Yoshikawa T, Sakashita N, Kato M. Zinc finger protein 28 as a novel melanoma-related molecule. (2009) J Dermatol Sci. 55, 68-70.

Kato M, Ohgami N, Kawamoto Y, Tsuzuki T, Hossain K, Yanagishita T, Ohshima Y, Tsuboi H, Yamanoshita O, Matsumoto Y, Takahashi M, Nakashima I. Protective Effect of Hyperpigmented Skin on UV-Mediated Cutaneous Cancer Development. J. Invest. Dermatol., 127, 1244-1249 (2007)

Kato M, Takeda K, Kawamoto Y, Hossain K, Ohgami N, Yanagishita T, Ohshima Y, Kato Y, Ohgami K, Yamamori T, Tateyama K, Yamanoshita O.Ultraviolet irradiation-mediated malignant melanoma induction with RET tyrosine kinase activation. 日本衛生学会雑誌 62(1):3-8 (2007)

Kato M, Takeda K, Kawamoto Y, Tsuzuki T, Kato Y, Ohno T, Hossain K, Iftakhar-E-Khuda I, Ohgami N, Isobe KI, Takahashi M, Nakashima I. Novel Hairless RET-Transgenic Mouse Line with Melanocytic Nevi and Anagen Hair Follicles. J. Invest. Dermatol., 126, 2547-2550 (2006)

Sugii, S., Lin, S., Ohgami, N., Ohashi, M., Chang, C. C., and Chang, T. Y., Roles of endogenously synthesized sterols in the endocytic pathway. J. Biol. Chem., 281, 23191-23206 (2006)

Chang, T. Y., Chang, C. C., Ohgami, N, and Yamauchi Y., Cholesterol Sensing, Trafficking, and Esterification. Annu. Rev. Cell Dev. Biol., 22, 129-157 (Review article) (2006)

Chang, T. Y., Reid, P. C., Sugii, S., Ohgami, N., Cruz, J. C., and Chang, C. C., Niemann-Pick type C disease and intracellular cholesterol trafficking. J. Biol. Chem., 280, 20917-20920 (Review article) (2005)

Ohgami, N., Ko, D. C., Thomas, M., Scott, M. P., Chang, C. C., and Chang, T. Y., Binding between the Niemann-Pick C1 protein and a photoactivatable cholesterol analog requires a functional sterol-sensing domain. Proc. Natl. Acad. Sci. USA. 101, 12473-12478 (2004)

Kuniyasu, A., Ohgami, N., Hayashi, S., Miyazaki, A., Horiuchi, S. and Nakayama, H., CD36-mediated endocytic uptake of advanced glycation end products (AGE) in mouse 3T3-L1 and human subcutaneous adipocytes. FEBS Lett., 537, 85-90 (2003)

Ohgami, N., Miyazaki, A., Sakai, M., Kuniyasu, A., Nakayama, H. and Horiuchi, S., Advanced glycation end products (AGE) inhibit scavenger receptor class B type I-mediated reverse cholesterol transport: a new crossroad of AGE to cholesterol metabolism. J. Atheroscler. Thromb., 10, 1-6. (Review article) (2003)

Sugii, S., Reid, P. C., Ohgami, N., Du, H. and Chang, T. Y., Distinct endosomal compartments in early trafficking of low density lipoprotein-derived cholesterol. J. Biol. Chem., 278, 27180-27189 (2003)

Sugii, S., Reid, P. C., Ohgami, N., Shimada, Y., Maue, R. A., Ninomiya, H., Ohno-Iwashita, Y. and Chang, T. Y., Biotinylated theta-toxin derivative as a probe to examine intracellular cholesterol-rich domains in normal and Niemann-Pick type C1 cells. J. Lipid Res., 44, 1033-1041 (2003)

Cruz, J. C., Thomas, M., Wong, E., Ohgami, N., Sugii, S., Curphey, T., Chang, C. C. and Chang, T. Y., Synthesis and biochemical properties of a new photoactivatable cholesterol analog 7,7-azocholestanol and its linoleate ester in Chinese hamster ovary cell lines. J. Lipid Res., 43, 1341-1347 (2002)

Ohgami, N., Nagai, R., Ikemoto, M., Arai, H., Miyazaki, A., Hakamata, H., Horiuchi, S. and Nakayama, H., CD36, serves as a receptor for advanced glycation endproducts (AGE). J. Diabetes Complications., 16, 56-59. (Review article) (2002)

Ohgami, N., Nagai, R., Ikemoto, M., Arai, H., Kuniyasu, A., Horiuchi, S. and Nakayama, H., CD36, a member of class B scavenger receptor family, is a receptor for advanced glycation end products. Ann. N. Y. Acad. Sci., 947, 350-355. (Review article) (2001)

Ohgami, N., Nagai, R., Miyazaki, A., Ikemoto, M., Arai, H., Horiuchi, S. and Nakayama, H., Scavenger receptor class B type I-mediated reverse cholesterol transport is inhibited by advanced glycation end products. J. Biol. Chem., 276, 13348-13355 (2001)

Ohgami, N., Nagai, R., Ikemoto, M., Arai, H., Kuniyasu, A., Horiuchi, S. and Nakayama, H., CD36, a member of the class b scavenger receptor family, as a receptor for advanced glycation end products. J. Biol. Chem., 276, 3195-3202 (2001)

Ohgami, N., Kuniyasu, A., Furukawa, K., Miyazaki, A., Hakamata, H., Horiuchi, S. and Nakayama, H., Glibenclamide acts as an inhibitor of acyl-CoA:cholesterol acyltransferase enzyme. Biochem. Biophys. Res. Commun., 277, 417-422 (2000)

講演、シンポジウム、学会発表

第78回日本衛生学会総会・シンポジウム（熊本、2008年3月28-31日）

第77回日本衛生学会総会（大阪、2007年3月25-28日）

Ara Parseghian Medical Research Foundation Scientific Conference on Niemann-Pick Type C Disease in June 2003 (AZ, USA) (2003)

Young Investigator Award presentation, the XIII International Symposium on Atherosclerosis., (Kyoko, Japan) (2003)等

第35回 日本動脈硬化学会 年会 若手研究者奨励賞 講演（2002）

受賞

The E. Lucile Smith Award for Scientific Excellence in Biochemistry from Dartmouth Medical School (NH, USA), 2005

The National Niemann-Pick Disease Foundation, 2004-2007

Young Investigator Award from the XIII International Symposium on Atherosclerosis, 2003

American Heart Association Postdoctoral Fellowship, 2002-2004

若手研究者奨励賞（第35回日本動脈硬化学会 年会）, 2002

社会活動

中部大学・国際保健ボランティア