中部大学

中部大学

教員情報

榊原 明 SAKAKIBARA Akira

プロフィール

職名 准教授
所属 生命健康科学部 作業療法学科
生命健康科学部 生命医科学科
作業療法実習センター
大学院 生命健康科学研究科 生命医科学専攻
人間力創成総合教育センター教養課題教育プログラム(科学リテラシー)
最終学歴 総合研究大学院大学大学院生命科学研究科生理科学専攻博士後期課程修了
学位 博士(学術)
所属学会・役職 日本細胞生物学会
日本神経科学学会
日本分子生物学会
American Society for Cell Biology
専門分野 解剖学、細胞生物学、神経科学
研究テーマ 脳形成メカニズムの解明、ニューロンの移動と極性化における細胞骨格の機能
授業科目 解剖・組織学、生と死の文化人類学、組織・病理学基礎実習、生体構築科学技術実習、臨床解剖学実習
共同研究キーワード 蛍光ライブイメージング、スライス培養

学術論文、評論

Shah, B., Lutter, D., Tsytsyura, Y., Glyvuk, N., Sakakibara, A., Klingauf, J., Püschel, A.W. (2017) Rap1 GTPases are master regulators of neural cell polarity in the developing neocortex. Cereb. Cortex 27:1253-1269

Shah, B., Lutter, D., Bochenek, M.L., Kato, K., Tsytsyura, Y., Glyvuk, N., Sakakibara, A., Klingauf, J., Adams, R.H., Püschel, A.W. (2016) C3G/Rapgef1 is required in multipolar neurons for the transition to a bipolar morphology during cortical development. PLoS One. 11:e0154174

Sakakibara, A., Hatanaka, Y. (2015) Neuronal polarization in the developing cerebral cortex. Front. Neurosci. 9:116

Sakakibara, A., Sato, T., Ando, R., Noguchi, N., Masaoka, M., Miyata, T. (2014) Dynamics of centrosome translocation and microtubule organization in neocortical neurons during distinct modes of polarization. Cereb. Cortex 24:1301-1310

Namba, T., Kibe, Y., Funahashi, Y., Nakamuta, S., Takano, T., Ueno, T., Shimada, A., Kozawa, S., Okamoto, M., Shimoda, Y., Oda, K., Wada, Y., Masuda, T., Sakakibara, A., Igarashi, M., Miyata, T., Faivre-Sarrailh, C., Takeuchi, K., Kaibuchi, K. (2014) Pioneering axons regulate neuronal polarization in the developing cerebral cortex. Neuron 81:814-829

Okamoto, M., Namba, T., Shinoda, T., Kondo, T., Watanabe, T., Inoue, Y., Takeuchi, K., Enomoto, Y., Ota, K., Oda, K., Wada, Y., Sagou, K., Saito, K., Sakakibara, A., Kawaguchi, A., Nakajima, K., Adachi, T., Fujimori, T., Ueda, M., Hayashi, S., Kaibuchi, K., Miyata, T. (2013) TAG-1-assisted progenitor elongation streamlines nuclear migration to optimize subpial crowding. Nat. Neurosci. 16:1556-1566

Sakakibara, A., Ando, R., Sapir, T., Tanaka, T. (2013) Microtubule dynamics in neuronal morphogenesis. Open Biol. 3:130061

Sapir, T., Levy, T., Sakakibara, A., Rabinkov, A., Miyata, T., Reiner, O. (2013) Shootin1 acts in concert with KIF20B to promote polarization of migrating neurons. J. Neurosci. 33:11932-11948

Xie, M.-J., Yagi, H., Kuroda, K., Wang, C.-C., Komada, M., Zhao, H., Sakakibara, A., Miyata, T., Nagata, K., Iguchi, T., Sato, M. (2013) WAVE2-Abi2 complex controls growth cone activity and regulates the multipolar-bipolar transition as well as the initiation of glia-guided migration. Cereb. Cortex 23:1410-1423

Pérez-Martínez, F.J., Luque-Río, Á., Sakakibara, A., Hattori, M., Miyata, T., Luque, J.M. (2012) Reelin-dependent ApoER2 downregulation uncouples newborn neurons from progenitor cells. Biol. Open 1:1258-1263

Nakamuta, S., Funahashi, Y., Namba, T., Arimura, N., Picciotto, M.R., Tokumitsu, H., Soderling, T.R., Sakakibara, A., Miyata, T., Kamiguchi, H., Kaibuchi, K. (2011) Local application of neurotrophins specifies axons through inositol 1,4,5-trisphosphate, calcium, and Ca2+/calmodulin-dependent protein kinases. Sci. Signal. 4: ra76

Miyata, T., Ono, Y., Okamoto, M., Masaoka, M., Sakakibara, A., Kawaguchi, A., Hashimoto, M., Ogawa, M. (2010) Migration, early axonogenesis, and Reelin-dependent layer-forming behavior of early/posterior born Purkinje cells in the developing mouse lateral cerebellum. Neural Dev. 5:23

Wang, Y., Nakayama, M., Pitulescu, M.E., Schmidt, T.S., Bochenek, M.L., Sakakibara, A., Adams, S., Davy, A., Deutsch, U., Barberis, A., Benjamin, L. E., Makinen, T., Nobes, C.D., Adams, R.H. (2010) Ephrin-B2 controls VEGF-induced angiogenesis and lymphangiogenesis. Nature 465:483-486

Minobe, S., Sakakibara, A., Ohdachi, T., Kanda, R., Kimura, M., Nakatani, S., Tadokoro, R., Ochiai, W., Nishizawa, Y., Mizoguchi, A., Kawauchi, T., Miyata, T. (2009) Rac is involved in the interkinetic nuclear migration of cortical progenitor cells. Neurosci. Res. 63:294-301

Ochiai, W., Nakatani, S., Takahara, T., Kainuma, M., Masaoka, M., Minobe, S., Namihira, M., Nakashima, K., Sakakibara, A., Ogawa, M., Miyata, T. (2009) Periventricular notch activation asymmetric Ngn2 and Tbr2 expression in pair-generated neocortical daughter cells. Mol. Cell. Neurosci. 40:225-233

Sakakibara, A., Horwitz, A.F. (2006) Mechanism of polarized protrusion formation on neuronal precursors migrating in the developing chicken cerebellum. J. Cell Sci. 119:3583-3592

Sakakibara, A., Hattori, S., Nakamura, S., Katagiri, T. (2003) A novel hematopoietic adaptor protein, Chat-H, positively regulates T cell receptor-mediated interleukin-2 production in Jurkat cells. J. Biol. Chem. 278:6012-6017

Sakakibara, A., Ohba, Y., Kurokawa, K., Matsuda, M., Hattori, S. (2002) Novel function of Chat in controlling cell adhesion via Cas-Crk-C3G-pathway-mediated Rap1 activation. J. Cell Sci. 115:4915-4924

Sakakibara, A., Hattori, S. (2000) Chat, a Cas/HEF1-associated adaptor protein that integrates multiple signaling pathways. J. Biol. Chem. 275:6404-6410

Moroi, S., Saitou, M., Fujimoto, K., Sakakibara, A., Furuse, M., Yoshida, O., Tsukita, S. (1998) Occludin is concentrated at tight junctions of mouse/rat but human/guinea pig Sertoli cells in testes. Am. J. Physiol. 274:C1708-C1717

Hashimoto, H., Sakakibara, A., Yamasaki, M. and Yoda, K. (1997) Saccharomyces cerevisiae VIG9 encodes GDP-mannose pyrophosphorylase, which is essential for protein glycosylation. J. Biol. Chem. 272:16308-16314

Sakakibara, A., Furuse, M., Saitou, M., Ando-Akatsuka, Y., Tsukita, S. (1997) Possible involvement of phosphorylation of occludin in tight junction formation. J. Cell Biol. 137:1397-1401

Ando-Akatsuka, Y., Saitou, M., Hirase, T., Kishi, M., Sakakibara, A., Itoh, M., Yonemura, S., Furuse, M., Tsukita, S. (1996) Interspecies diversity of occludin sequence: cDNA cloning of human, mouse, dog, and rat-kangaroo homologues. J. Cell Biol. 133:43-47

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