中部大学

中部大学

教員情報

武田 湖州恵 TAKEDA Kozue

プロフィール

職名 准教授
所属 生命健康科学部 理学療法学科
生命健康科学部 生命医科学科
理学療法実習センター
大学院 生命健康科学研究科 生命医科学専攻
最終学歴 名古屋大学大学院医学系研究科
学位 博士(医学)
資格 医師
所属学会・役職 日本内科学会
日本腎臓学会
日本透析医学会
日本免疫学会
日本癌学会
専門分野 免疫学、分子生物学
研究テーマ チロシンキナーゼのレドックス修飾を介した活性制御機構の解析、悪性腫瘍発生・制御因子に関する研究、皮膚アレルギー
授業科目 免疫学、生体防御学、生命科学入門、内分泌腎臓内科学、免疫学実習など

学術論文、評論

Peptides containing the MXXCW motif inhibit oncogenic RET kinase activity with a novel mechanism of action. Takeda K, Kawamoto Y, Nagasaki Y, Okuno Y, Goto Y, Iida M, Yajima I, Ohgami N, Kato M. Am J Cancer Res. 2020 Jan 1;10(1):336-349.

Inhibition of mast cell degranulation by melanin. Kawamoto Y, Kondo H, Hasegawa M, Kurimoto C, Ishii Y, Kato C, Botei T, Shinya M, Murate T, Ueno Y, Kawabe M, Goto Y, Yamamoto R, Iida M, Yajima I, Ohgami N, Kato M, Takeda K. Biochem Pharmacol. 2019 May;163:178-193.

Improvement of balance in young adults by a sound component at 100?Hz in music. Xu H, Ohgami N, He T, Hashimoto K, Tazaki A, Ohgami K, Takeda K, Kato M. Sci Rep. 2018 Nov 15;8(1):16894.

The effects of non-thermal atmospheric pressure plasma irradiation on expression levels of matrix metalloproteinases in benign melanocytic tumors in RET-transgenic mice. Iida M, Yajima I, Ohgami N, Tamura H, Takeda K, Ichihara S, Hori M, Kato M. Eur J Dermatol. 2014 May-Jun;24(3):392-4.

Control of genetically prescribed protein tyrosine kinase activities by environment-linked redox reactions. Nakashima I, Kawamoto Y, Takeda K, Kato M. Enzyme Res. 2011.

L-cysteine as a regulator for arsenic-mediated cancer-promoting and anti-cancer effects. Kato M, Kumasaka MY, Takeda K, Hossain K, Iida M, Yajima I, Goto Y, Ohgami N. Toxicol In Vitro. 2011; 25(3):623-9

c-RET molecule in malignant melanoma from oncogenic RET-carrying transgenic mice and human cell lines. Ohshima Y, Yajima I, Takeda K, Iida M, Kumasaka M, Matsumoto Y, Kato M. PLoS One. 2010; 5(4):e10279.

A redox-linked novel pathway for arsenic-mediated RET tyrosine kinase activation. Kato M, Takeda K, Hossain K, Thang ND, Kaneko Y, Kumasaka M, Yamanoshita O, Uemura N, Takahashi M, Ohgami N, Kawamoto Y. J Cell Biochem. 2010; 110(2):399-407.

Induction of autoimmunity in a bleomycin-induced murine model of experimental systemic sclerosis: an important role for CD4+ T cells. Ishikawa H, Takeda K, Okamoto A, Matsuo S, Isobe K. J Invest Dermatol. 2009; 129(7):1688-95.

The vacuolar V1/V0-ATPase is involved in the release of the HOPS subunit Vps41 from vacuoles, vacuole fragmentation and fusion. Takeda K, Cabrera M, Rohde J, Bausch D, Jensen ON, Ungermann C. FEBS Lett. 2008; 582(10):1558-63.

Novel hairless RET-transgenic mouse line with melanocytic nevi and anagen hair follicles. Kato M, Takeda K, Kawamoto Y, Tsuzuki T, Kato Y, Ohno T, Hossain K, Iftakhar-E-Khuda I, Ohgami N, Isobe K, Takahashi M, Nakashima I. J Invest Dermatol. 2006; 126(11):2547-50.

A PKC-mediated backup mechanism of the MXXCW motif-linked switch for initiating tyrosine kinase activities. Takeda K, Kawamoto Y, Okuno Y, Kato M, Takahashi M, Suzuki H, Isobe K, Nakashima I. FEBS Lett. 2006; 580(3):839-43.

CD8+CD122+ regulatory T cells produce IL-10 to suppress IFN-gamma production and proliferation of CD8+ T cells. Endharti AT, Rifa'I M, Shi Z, Fukuoka Y, Nakahara Y, Kawamoto Y, Takeda K, Isobe K, Suzuki H. J Immunol. 2005; 175(11):7093-7.

Paeoniflorin induces apoptosis of lymphocytes through a redox-linked mechanism. Tsuboi H, Hossain K, Akhand AA, Takeda K, Du J, Rifa'i M, Dai Y, Hayakawa A, Suzuki H, Nakashima I. J Cell Biochem. 2004; 93(1):162-72.

c-Kit-targeting immunotherapy for hereditary melanoma in a mouse model. Kato M, Takeda K, Kawamoto Y, Tsuzuki T, Hossain K, Tamakoshi A, Kunisada T, Kambayashi Y, Ogino K, Suzuki H, Takahashi M, Nakashima I. Cancer Res. 2004; 64(3):801-6.

Identification of RET autophosphorylation sites by mass spectrometry. Kawamoto Y, Takeda K, Okuno Y, Yamakawa Y, Ito Y, Taguchi R, Kato M, Suzuki H, Takahashi M, Nakashima I. J Biol Chem. 2004; 279(14):14213-24.

Protein phosphatase 2A-linked and -unlinked caspase-dependent pathways for downregulation of Akt kinase triggered by 4-hydroxynonenal. Liu W, Akhand AA, Takeda K, Kawamoto Y, Itoigawa M, Kato M, Suzuki H, Ishikawa N, Nakashima I. Cell Death Differ. 2003; 10(7):772-81.

Repair by Src kinase of function-impaired RET with multiple endocrine neoplasia type 2A mutation with substitutions of tyrosines in the COOH-terminal kinase domain for phenylalanine. Kato M, Takeda K, Kawamoto Y, Iwashita T, Akhand AA, Senga T, Yamamoto M, Sobue G, Hamaguchi M, Takahashi M, Nakashima I. Cancer Res. 2002; 62(8):2414-22.

RET tyrosine kinase enhances hair growth in association with promotion of melanogenesis. Kato M, Takeda K, Kawamoto Y, Tsuzuki T, Dai Y, Nakayama S, Toriyama K, Tamada Y, Takahashi M, Nakashima I. Oncogene. 2001; 20(51):7536-41.

T-cell-immunity-based inhibitory effects of orally administered herbal medicine juzen-taiho-to on the growth of primarily developed melanocytic tumors in RET-transgenic mice. Dai Y, Kato M, Takeda K, Kawamoto Y, Akhand AA, Hossain K, Suzuki H, Nakashima I. J Invest Dermatol. 2001; 117(3):694-701.

Osmotic stress-mediated activation of RET kinases involves intracellular disulfide-bonded dimer formation. Takeda K, Kato M, Wu J, Iwashita T, Suzuki H, Takahashi M, Nakashima I. Antioxid Redox Signal. 2001; 3(3):473-82.

Ultraviolet radiation induces both full activation of ret kinase and malignant melanocytic tumor promotion in RFP-RET-transgenic mice. Kato M, Liu W, Akhand AA, Hossain K, Takeda K, Takahashi M, Nakashima I. J Invest Dermatol. 2000; 115(6):1157-8.

Arsenite induces apoptosis of murine T lymphocytes through membrane raft-linked signaling for activation of c-Jun amino-terminal kinase. Hossain K, Akhand AA, Kato M, Du J, Takeda K, Wu J, Takeuchi K, Liu W, Suzuki H, Nakashima I. J Immunol. 2000; 165(8):4290-7.

Ultraviolet light induces redox reaction-mediated dimerization and superactivation of oncogenic Ret tyrosine kinases. Kato M, Iwashita T, Takeda K, Akhand AA, Liu W, Yoshihara M, Asai N, Suzuki H, Takahashi M, Nakashima I. Mol Biol Cell. 2000; 11(1):93-101.

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