中部大学

中部大学

教員情報

禹 済泰 WOO Je-Tae

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プロフィール

生年 1961
出身 大韓民国
職名 教授
所属 応用生物学部 応用生物化学科
大学院 応用生物学研究科 応用生物学専攻
生物機能開発研究所
創造的リベラルアーツセンター
最終学歴 東京農工大学大学院農学研究科
学位 博士(農学)(東京農工大学)
博士(医学)(東京医科大学)
所属学会・役職 日本農芸化学会
日本動物細胞工学会
アメリカ骨代謝学会
専門分野 天然物化学、生理活性細胞化学、生物化学
研究テーマ 天然生理活性物質の探索とその分子・細胞・器官・個体レベルでの作用機構解析
研究紹介PDF
授業科目 天然物化学、生理活性細胞生化学、細胞工学

著書および訳書

Dietary flavonoids and their effects on osteoclast differentiation and function. Bromacology: Pharmacology of Foods and Their Components Research Signpost, 35-52., 2008

Cahallenges of nutriproteimics for Bromacology Bromacology: Pharmacology of Foods and Their Components Research Signpost., 171-188., 2008

学術論文、評論

Nam SH, Yamano A, Kim JA, Lim J, Baek SH, Kim JE, Kwon TG, Saito Y, Teruya T, Choi SY, Kim YK, Bae YC, Shin HI, Woo JT, Park EK. Prenylflavonoids isolated from Macaranga tanarius stimulate odontoblast differentiation of human dentalpulp stem cells and tooth root formation via the mitogen-activated proteinkinase and protein kinase B pathways. Int Endod J. 2021 Feb 28. doi:10.1111/iej.13503. Epub ahead of print. PMID: 33641170.

Natsume N, Yamano A, Watanabe A, Yonezawa T, Woo JT, Yamakuni T, Teruya T. Effect of methoxyflavones contained in Kaempferia parviflora on CRE-mediatedtranscription in PC12D cells. Bioorg Med Chem Lett. 2020 Dec 1;30(23):127606.doi: 10.1016/j.bmcl.2020.127606. Epub 2020 Oct 7. PMID: 33038547.

Natsume N, Yonezawa T, Woo JT, Teruya T. Effect of pinocembrin isolated from Alpinia zerumbet on osteoblast differentiation. Cytotechnology. 2020 Oct 7. doi:10.1007/ s10616-020-00427-2. Epub ahead of print. PMID: 33029744.

Tsuboi T, Lu R, Yonezawa T, Watanabe A, Woo JT, Abe-Dohmae S, Yokoyama S. Molecular mechanism for nobiletin to enhance ABCA1/G1 expression in mouse macrophages. Atherosclerosis. 2020 Mar;297:32-39. doi:10.1016/j. atherosclerosis. 2020.01.024. Epub 2020 Feb 6. PMID: 32062137.

Kim YJ, Kim SR, Kim DY, Woo JT, Kwon EY, Han Y, Choi MS, Jung UJ. Supplementation of the Flavonoid Myricitrin Attenuates the Adverse Metabolic Effects of Long-Term Consumption of a High-Fat Diet in Mice. J Med Food. 2019 Nov;22(11):1151-1158. doi: 10.1089/jmf.2018.4341. Epub 2019 Sep 24. PMID: 31549892.

Lee JH, Kim YG, Khadke SK, Yamano A, Woo JT, Lee J. Antimicrobial andantibiofilm activities of prenylated flavanones from Macaranga tanarius. Phytomedicine. 2019 Oct;63:153033. doi: 10.1016/j.phymed.2019.153033. Epub 2019 Jul 13. PMID: 31352284.

Segawa R, Shiraki M, Sudo S, Shigeeda K, Saito T, Mizuno N, Moriya T,Yonezawa T, Woo JT, Hiratsuka M, Hirasawa N. A chalcone derivative suppresses the induction of TSLP in mice and human keratinocytes and attenuates OVA-induced antibody production in mice. Eur J Pharmacol. 2019 May 15;851:52-62. doi: 10.1016/ j.ejphar.2019.02.007. Epub 2019 Feb 10. PMID: 30753864.

Weng Y, Wang J, Yang Z, Xi M, Duan J, Guo C, Yin Y, Segawa R, Moriya T,Yonezawa T, Cha BY, Woo JT, Wen A, Hirasawa N. A steroid alkaloid derivative 02F04 upregulates thymic stromal lymphopoietin expression slowly and continuously through a novel Gq/11-ROCK-ERK1/2 signaling pathway in mouse keratinocytes. Cell Signal. 2019 May;57:58-64. doi: 0.1016/j.cellsig.2019.01.005. Epub 2019 Jan 19. PMID: 30664940.

Mitani Y, Satake K, Tsukamoto M, Nakamura I, Kadioglu O, Teruya T, Yonezawa T, Cha BY, Efferth T, Woo JT, Nakagawa H. Epimagnolin A, a tetrahydrofurofuranoid lignan from Magnolia fargesii, reverses ABCB1-mediated drug resistance. Phytomedicine. 2018 Dec 1;51:112-119. doi: 10.1016/j.phymed.2018.06.030. Epub 2018 Jun 20. PMID: 30466608.

Fujiwara N, Lee JW, Kumakami-Sakano M, Otsu K, Woo JT, Iseki S, Ota MS. Harmine promotes molar root development via SMAD1/5/8 phosphorylation. Biochem Biophys Res Commun. 2018 Mar 11;497(3):924-929. doi: 10.1016/j.bbrc.2017.12.062. Epub 2017 Dec 15. PMID: 29253570.

Weng Y, Mizuno N, Dong J, Segawa R, Yonezawa T, Cha BY, Woo JT, Moriya T, Hiratsuka M, Hirasawa N. Induction of thymic stromal lymphopoietin by a steroid alkaloid derivative in mouse keratinocytes. Int Immunopharmacol. 2018 Feb;55:28-37. doi: 10.1016/j.intimp.2017.11.045. Epub 2017 Dec 22. PMID: 29220720.

Minami M, Mori T, Yonezawa T, Saito Y, Teruya T, Woo JT. Evaluation of raw nepodin extraction from Rumex japonicus and R. obtusifolius and their DNA polymorphisms. J Nat Med. 2018 Jan;72(1):369-374. doi: 10.1007/s11418-017-1143-0. Epub 2017 Oct 23. PMID: 29063361.

Kim NT, Lee DS, Chowdhury A, Lee H, Cha BY, Woo JT, Woo ER, Jang JH. Acerogenin C from Acer nikoense exhibits a neuroprotective effect in mouse hippocampal HT22 cell lines through the upregulation of Nrf-2/HO-1 signaling pathways. Mol Med Rep. 2017 Aug;16(2):1537-1543. doi: 10.3892/mmr.2017.6682. Epub 2017 Jun 2. PMID: 28586034.

Kim YJ, Choi MS, Woo JT, Jeong MJ, Kim SR, Jung UJ. Long-term dietary supplementation with low-dose nobiletin ameliorates hepatic steatosis, insulin resistance, and inflammation without altering fat mass in diet-induced obesity. Mol Nutr Food Res. 2017 Aug;61(8). doi: 10.1002/mnfr.201600889. Epub 2017 Mar 2. PMID: 28116779.

Eun SH, Woo JT, Kim DH. Tangeretin Inhibits IL-12 Expression and NF-κB Activation in Dendritic Cells and Attenuates Colitis in Mice. Planta Med. 2017 Apr;83(6):527-533. doi: 10.1055/s-0042-119074. Epub 2016 Nov 2. PMID: 27806407.

Lee DS, Cha BY, Woo JT, Kim YC, Jang JH. Acerogenin A from Acer nikoense Maxim Prevents Oxidative Stress-Induced Neuronal Cell Death through Nrf2-Mediated Heme Oxygenase-1 Expression in Mouse Hippocampal HT22 Cell Line. Molecules. 2015 Jul 9;20(7):12545-57. doi: 10.3390/molecules200712545. PMID: 26184139; PMCID: PMC6331826.

Kim HJ, Kim JS, Woo JT, Lee IS, Cha BY. Hyperpigmentation mechanism of methyl 3,5-di-caffeoylquinate through activation of p38 and MITF induction of tyrosinase. Acta Biochim Biophys Sin (Shanghai). 2015 Jul;47(7):548-56. doi: 10.1093/abbs/gmv040. Epub 2015 May 27. PMID: 26018825.

Kim HJ, Kim IS, Dong Y, Lee IS, Kim JS, Kim JS, Woo JT, Cha BY. Melanogenesis -inducing effect of cirsimaritin through increases in microphthalmia-associated transcription factor and tyrosinase expression. Int J Mol Sci. 2015 Apr 20;16(4):8772-88. doi: 10.3390/ijms16048772. PMID: 25903150; PMCID: PMC4425108.

Kim HJ, Yonezawa T, Teruya T, Woo JT, Cha BY. Nobiletin, a polymethoxy flavonoid, reduced endothelin-1 plus SCF-induced pigmentation in human melanocytes. Photochem Photobiol. 2015 Mar-Apr;91(2):379-86. doi: 10.1111/php.12400. Epub 2015 Jan 12. PMID: 25488359.

Lee JW, Asai M, Jeon SK, Iimura T, Yonezawa T, Cha BY, Woo JT, Yamaguchi A. Rosmarinic acid exerts an antiosteoporotic effect in the RANKL-induced mouse model of bone loss by promotion of osteoblastic differentiation and inhibition of osteoclastic differentiation. Mol Nutr Food Res. 2015 Mar;59(3):386-400. doi: 10.1002/mnfr. 201400164. Epub 2015 Jan 21. PMID: 25380345.

Ha BG, Yonezawa T, Son MJ, Woo JT, Ohba S, Chung UI, Yagasaki K. Antidiabetic effect of nepodin, a component of Rumex roots, and its modes of action in vitro and in vivo. Biofactors. 2014 Jul-Aug;40(4):436-47. doi: 10.1002/biof.1165. Epub 2014 Apr 23. PMID: 24756979.

その他

特許公開平11-246406, 骨吸収抑制剤

特許公開平11-246405, 骨吸収抑制剤

特許公開平08-092193, チオールプロテアーゼ阻害剤及び骨吸収阻害剤, ならびにペプチド誘導体

特許公開平08-081489, ポリガラクツロナーゼ阻害剤

特許公開平07-070098, 生理活性ペプチド系化合物

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