中部大学

中部大学

教員情報

鶴留 雅人 TSURUDOME Masato

プロフィール

生年 1955
出身 鹿児島県
職名 教授
所属 生命健康科学部 生命医科学科
臨床検査技術教育・実習センター
大学院 生命健康科学研究科 生命医科学専攻
最終学歴 東京大学農学部畜産獣医学科卒業
学位 農学博士(東京大学)、博士(医学)(三重大学)
資格 獣医師
所属学会・役職 日本ウイルス学会
日本獣医学会
American Society for Microbiology
専門分野 ウイルス学、分子生物学
研究テーマ ウイルスによる膜融合誘導の分子機構の解明
研究紹介PDF
授業科目 微生物学、分子感染論、感染防御技術論、感染症予防医科学

著書および訳書

『Negative Strand RNA Virus』(共著), World Scientific Publishing Co. Pte. Ltd., 2011年

『Viral Fusion Mechanisms』(共著), CRC Press, 1993年

学術論文、評論

32. Ohtsuka J, Fukumura M, Furuyama W, Wang S, Hara K, Maeda M, Tsurudome M, Miyamoto H, Kaito A, Tsuda N, Kataoka Y, Mizoguchi A, Takada A, Nosaka T. A versatile platform technology for recombinant vaccines using non-propagative human parainfluenza virus type 2 vector. Sci Rep. 9:12901. 2019.

31. Ohtsuka J, Matsumoto Y, Ohta K, Fukumura M, Tsurudome M, Nosaka T, and Nishio M. Nucleocytoplasmic shuttling of the human parainfluenza virus type 2 phosphoprotein. Virology 528:54-63. 2018.

30. Tsurudome M, Ohtsuka J, Ito M, Nishio M, and Nosaka T: The hemagglutinin-neuraminidase (HN) head domain and the fusion (F) protein stalk domain of the parainfluenza viruses affect the specificity of the HN-F interaction. Front. Microbiol. 9:Article 391, 2018.

29. Goto H, Ihira H, Morishita K, Tsuchiya M, Ohta K, Yumine N, Tsurudome M, and Nishio M: Enhanced growth of influenza A virus by coinfection with human parainfluenza virus type 2. Med. Microbiol. Immunol. 205:209-218, 2016.

28. Ohta K, Goto H, Matsumoto Y, Yumine N, Tsurudome M, and Nishio M: Graf1 controls the growth of human parainfluenza virus type 2 through inactivation of RhoA signaling. J. Virol. 90:9394-9405, 2016.

27. Ito M, Kubota H, Takeuchi T, Qiao S, Tsurudome M:, Tsumura H, Matsuda A, Nishio M, and Ito Y. Pathogenesis of the influenza virus in diabetes model mice. Brit. Microbiol,. Res J. 9:1-7 2015.

26. Tsurudome M, Ito M, Ohtsuka J, Hara K, Komada H, Nishio M, and Nosaka T: The fusion protein specificity of the parainfluenza virus hemagglutinin- neuraminidase protein is not solely defined by the primary structure of its stalk domain. J. Virol. 89:12374-12387, 2015.

25. Ohtsuka J, Fukumura M, Tsurudome M, Hara K, Nishio M, Kawano M, and Nosaka T: Vero/BC-F: an efficient packaging cell line stably expressing F protein to generate single round-infectious human parainfluenza virus type 2 vector. Gene Ther. 21:775-784, 2014.

24. Tsurudome M, Nakahashi M, Matsushima Y, Ito M, Nishio M, Kawano M, Komada H, and Nosaka T: Full conversion of the hemagglutinin- neuraminidase specificity of the parainfluenza virus 5 fusion protein by replacement of 21 amino acids in its head region with those of the simian virus 41 fusion protein. J. Virol. 87:8342-8350, 2013.

23. Tsurudome M, Ito M, Nishio M, Nakahashi M, Kawano M, Komada H, Nosaka T, and Ito Y: Identification of domains on the fusion (F) protein trimer that influence the hemagglutinin-neuraminidase specificity of the f protein in mediating cell-cell fusion. Virol. 85:3153-3161, 2011.

22. Nishio M, Tsurudome M, Garcin D, Komada H, Ito M, Le Mercier P, Nosaka T, and Kolakofsky D: Human parainfluenza virus type 2 L protein regions required for interaction with other viral proteins and mRNA capping. J. Virol. 85:725-732, 2011.

21. Ito M, Yamakawa I, Nishio M, Tsurudome M, Kawano M, Komada H, and Ito Y: A quantitative method for analyzing establishing-efficiency of persistent viral infection. Microbiol. Immunol. 53:259-265, 2009.

20. Tsurudome M, Nishio M, Ito M, Tanahashi S, Kawano M, Komada H, and Ito Y: Effects of hemagglutinin-neuraminidase protein mutations on cell-cell fusion mediated by human parainfluenza type 2 virus. J. Virol. 82:8283-8295, 2008.

19. Nishio M, Ohtsuka J, Tsurudome M, Nosaka T, and Kolakofsky D: Human parainfluenza virus type 2 V protein inhibits genome replication by binding to the L protein: possible role in promoting viral fitness. J. Virol. 82:6130-6138, 2008.

18. Ito M, Nishio M, Kawano M, Komada M, Ito Y, and Tsurudome M: Effects of multiple amino acids of the parainfluenza virus 5 fusion protein on the haemagglutinin- neuraminidase-independent fusion activity. J. Gen. Virol. 90:405-413, 2009.

17. Ohkubo T, Nishio M, Tsurudome M, Ito M, and Ito Y: Existence of leptin receptor protein in chicken tissues: isolation of a monoclonal antibody against chicken leptin receptor. Gen. Comp. Endocrinol. 151:269-273, 2007.

16. Tsurudome M, Ito M, Nishio M, Kawano M, Komada H, and Ito Y: A mutant fusion (F) protein of simian virus 5 induces hemagglutinin-neuraminidase- independent syncytium formation despite the internalization of the F protein. Virology 347:11-27, 2006.

15. Ito M, Takeuchi T, Nishio M, Kawano M, Komada H, Tsurudome M, and Ito Y: Early stage of establishment of persistent Sendai virus infection: unstable dynamic phase and then selection of viruses which are tightly cell associated, temperature sensitive, and capable of establishing persistent infection. J. Virol. 78:11939-11951, 2004.

14. Okamoto Y, Sakata M, Ogura K, Yamamoto T, Yamaguchi M, Tasaka K, Kurachi H, Tsurudome M, and Murata Y: Expression and regulation of 4F2hc and hLAT1 in human trophoblasts. Am. J. Physiol Cell Physiol. 282:C196-C204, 2002.

13. Ito M, Takebayashi S-I, Okumura K, Ohkubo T, Nishio M, Kawano M, Komada H, Ito Y, and Tsurudome M: Up-regulated expression of a novel gene in activated human peripheral blood mononuclear cells that is a truncated paralog of the human system L-amino acid transporter 1. Int. J. Biochem. Cell Biol. 34:1152-1163, 2002.

12. Tsurudome M, Ito M, Nishio M, Kawano M, Komada H, and Ito Y: Hemagglutinin-neuraminidase-independent fusion activity of simian virus 5 fusion (F) protein: difference in conformation between fusogenic and nonfusogenic F proteins on the cell surface. J. Virol. 75:8999-9009, 2001.

11. Ito M, Nishio M, Komada H, Ito Y, and Tsurudome M: An amino acid in the heptad repeat 1 domain is important for the haemagglutinin-neuraminidase- independent fusing activity of simian virus 5 fusion protein. J. Gen. Virol. 81:719-727, 2000.

10. Tsurudome M, Ito M, Takebayashi S-I, Okumura K, Nishio M, Kawano M, Kusagawa S, Komada H, and Ito Y: Cutting edge: Primary structure of the light chain of fusion regulatory protein-1/CD98/4F2 predicts a protein with multiple transmembrane domains that is almost identical to the amino acid transporter E16. J. Immunol. 162:2462-2466, 1999.

9. Tsurudome M, Ito M, Nishio M, Kawano M, Okamoto K, Kusagawa S, Komada H, and Ito Y: Identification of regions on the fusion protein of human parainfluenza virus type 2 which are required for haemagglutinin-neuraminidase proteins to promote cell fusion. J. Gen. Virol. 79:279-289, 1998.

8. Ito M, Nishio M, Kawano M, Kusagawa S, Komada H, Ito Y, and Tsurudome M: Role of a single amino acid at the amino terminus of the simian virus 5 F2 subunit in syncytium formation. J. Virol. 71:9855-9858, 1997.

7. Tsurudome M, Kawano M, Yuasa T, Tabata N, Nishio M, Komada H, and Ito Y: Identification of regions on the hemagglutinin-neuraminidase protein of human parainfluenza virus type 2 important for promoting cell fusion. Virology 213:190-203, 1995.

6. Yuasa T, Kawano M, Tabata N, Nishio M, Kusagawa S, Komada H, Matsumura H, Ito Y, and Tsurudome M: A cell fusion-inhibiting monoclonal antibody binds to the presumed stalk domain of the human parainfluenza type 2 virus hemagglutinin-neuraminidase protein. Virology 206:1117-1125, 1995.

5. Tsurudome M, Glück R, Graf R, Falchetto R, Schaller U, and Brunner J: Lipid interactions of the hemagglutinin HA2 NH2-terminal segment during influenza virus-induced membrane fusion. J. Biol. Chem. 267:20225-20232, 1992.

4. Tsurudome M, Bando H, Kawano M, Matsumura H, Komada H, Nishio M, and Ito Y: Transcripts of simian virus 41 (SV41) matrix gene are exclusively dicistronic with the fusion gene which is also transcribed as a monocistron. Virology 184:93-100, 1991.

3. Tsurudome M, Bando H, Nishio M, Iwamoto Y, Kawano M, Kondo K, Komada H, and Ito Y: Antigenic and structural properties of a paramyxovirus simian virus 41 (SV41) reveal a close relationship with human parainfluenza type 2 virus. Virology 179:738-748, 1990.

2. Tsurudome M, Nishio M, Komada H, Bando H, and Ito Y: Extensive antigenic diversity among human parainfluenza type 2 virus isolates and immunological relationships among paramyxoviruses revealed by monoclonal antibodies. Virology 171:38-48, 1989.

1. Tsurudome M, Yamada A, Hishiyama M, and Ito Y: Monoclonal antibodies against the glycoproteins of mumps virus: fusion inhibition by anti-HN monoclonal antibody. J. Gen. Virol. 67:2259-2265, 1986.

講演、シンポジウム、学会発表

7. Tsurudome M, Ito M, Nishio M. The hemagglutinin-neuraminidase (HN) head domain and the fusion (F) protein stalk domain of the parainfluenza viruses affect the specificity of the HN-F interaction. XVII International Conference on Negative Strand Viruses,Verona (Italy), 2018.

6. Tsurudome M, Ito M, Nishio M, Nosaka T. The F specificity of the parainfluenza virus HN is not defined solely by the primary structure of the HN stalk domain. XVI International Conference on Negative Strand Viruses, Siena (Italy), 2015.

5. Tsurudome M, Ito M, Nishio M, and Nosaka T. Conversion of the parainfluenza virus 5 F protein to a simian virus 41 HN-specific protein by amino acid substitutions. XV International Conference on Negative Strand Viruses, Granada(Spain), 2013.

4. Tsurudome M, Ito M, Nishio M, and Ito Y: Identification of domains on the trimer surface of the fusion (F) protein that influence the hemagglutinin-neuraminidase specificity of the F protein in mediating cell-cell fusion. XIV International Conference on Negative Strand Viruses, Brugge (Belgium), 2010.

3. Tsurudome M, Nishio M, Ohtsuka J, and Kawano M: Mapping of the domains on the paramyxovirus fusion protein that determine hemagglutinin-neuraminidase specificity in mediating syncytium formation. Workshop on Replication and Cell Biology of Negative Strand RNA Viruses, Evanston (USA), 2007.

2. Bateman A, Chinnery F, Tsurudome M, King C, Khakoo S, and Elliott T: Paramyxovirus HN expression promotes tumor immunity via NK activation. Keystone Symposia: Basic Aspects of Tumor Immunology, Keystone (USA), 2005.

1. Tsurudome M, Ito M, Nishio M, and Ito Y: Hemagglutinin-neuraminidase-independent fusing activity of simian virus 5 fusion protein: involvement of a conformational change in the head domain. XII International Conference on Negative Strand Viruses, Pisa (Italy), 2003.

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