中部大学

中部大学

教員情報

米澤 貴之 YONEZAWA Takayuki

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プロフィール

職名 准教授
所属 生物機能開発研究所
最終学歴 東北大学大学院医学系研究科障害科学専攻博士前期課程修了
学位 博士(薬学)(東北大学)
資格 薬剤師
所属学会・役職 日本薬学会
日本農芸化学会
日本動物細胞工学会
専門分野 天然物化学、細胞生物学
研究テーマ 天然素材の機能性に関する研究
共同研究キーワード 骨代謝、糖代謝、脂質代謝、かゆみ

学術論文、評論

Natsume N, Yamano A, Watanabe A, Yonezawa T, Woo JT, Yamakuni T, Teruya T. Effect of methoxyflavones contained in Kaempferia parviflora on CRE-mediated transcription in PC12D cells. Bioorg Med Chem Lett. 2020 Dec 1;30(23):127606. doi:10.1016/j.bmcl.2020.127606. Epub 2020 Oct 7. PMID: 33038547.

Natsume N, Yonezawa T, Woo JT, Teruya T. Effect of pinocembrin isolated from Alpinia zerumbet on osteoblast differentiation. Cytotechnology. 2020 Oct 7. doi: 10.1007/s10616-020-00427-2. Epub ahead of print. PMID: 33029744.

Tsuboi T, Lu R, Yonezawa T, Watanabe A, Woo JT, Abe-Dohmae S, Yokoyama S. Molecular mechanism for nobiletin to enhance ABCA1/G1 expression in mouse macrophages. Atherosclerosis. 2020 Mar;297:32-39. doi:10.1016/j.atherosclerosis.2020.01.024. Epub 2020 Feb 6. PMID: 32062137.

Weng Y, Wang J, Yang Z, Xi M, Duan J, Guo C, Yin Y, Segawa R, Moriya T, Yonezawa T, Cha BY, Woo JT, Wen A, Hirasawa N. A steroid alkaloid derivative 02F04 upregulates thymic stromal lymphopoietin expression slowly and continuously through a novel Gq/11-ROCK-ERK1/2 signaling pathway in mouse keratinocytes. Cell Signal. 2019 May;57:58-64. doi:10.1016/j.cellsig.2019.01.005. Epub 2019 Jan 19. PMID: 30664940.

Segawa R, Shiraki M, Sudo S, Shigeeda K, Saito T, Mizuno N, Moriya T, Yonezawa T, Woo JT, Hiratsuka M, Hirasawa N. A chalcone derivative suppresses the induction of TSLP in mice and human keratinocytes and attenuates OVA-induced antibody production in mice. Eur J Pharmacol. 2019 May 15;851:52-62. doi:10.1016/j.ejphar.2019.02.007. Epub 2019 Feb 10. PMID: 30753864.

Kikuchi H, Kawai K, Nakashiro Y, Yonezawa T, Kawaji K, Kodama EN, Oshima Y. Construction of a Meroterpenoid-Like Compounds Library Based on Diversity- Enhanced Extracts. Chemistry. 2019 Jan 18;25(4):1106-1112. doi: 10.1002/chem.201805417. Epub 2018 Dec 13. PMID: 30379362.

Mitani Y, Satake K, Tsukamoto M, Nakamura I, Kadioglu O, Teruya T, Yonezawa T, Cha BY, Efferth T, Woo JT, Nakagawa H. Epimagnolin A, a tetrahydrofurofuranoid lignan from Magnolia fargesii, reverses ABCB1-mediated drug resistance. Phytomedicine. 2018 Dec 1;51:112-119. doi:10.1016/j.phymed.2018.06.030. Epub 2018 Jun 20. PMID: 30466608.

Weng Y, Mizuno N, Dong J, Segawa R, Yonezawa T, Cha BY, Woo JT, Moriya T, Hiratsuka M, Hirasawa N. Induction of thymic stromal lymphopoietin by a steroid alkaloid derivative in mouse keratinocytes. Int Immunopharmacol. 2018 Feb;55:28-37. doi:10.1016/j.intimp.2017.11.045. Epub 2017 Dec 22. PMID:29220720.

Minami M, Mori T, Yonezawa T, Saito Y, Teruya T, Woo JT. Evaluation of raw nepodin extraction from Rumex japonicus and R. obtusifolius and their DNA polymorphisms. J Nat Med. 2018 Jan;72(1):369-374. doi:10.1007/s11418-017-1143-0. Epub 2017 Oct 23. PMID: 29063361.

Lee JW, Asai M, Jeon SK, Iimura T, Yonezawa T, Cha BY, Woo JT, Yamaguchi A. Rosmarinic acid exerts an antiosteoporotic effect in the RANKL-induced mouse model of bone loss by promotion of osteoblastic differentiation and inhibition of osteoclastic differentiation. Mol Nutr Food Res. 2015 Mar;59(3):386-400. doi:10.1002/mnfr.201400164. Epub 2015 Jan 21. PMID: 25380345.

Kim HJ, Yonezawa T, Teruya T, Woo JT, Cha BY. Nobiletin, a polymethoxy flavonoid, reduced endothelin-1 plus SCF-induced pigmentation in human melanocytes. Photochem Photobiol. 2015 Mar-Apr;91(2):379-86. doi:10.1111/php.12400. Epub 2015 Jan 12. PMID: 25488359.

Ha BG, Yonezawa T, Son MJ, Woo JT, Ohba S, Chung UI, Yagasaki K. Antidiabetic effect of nepodin, a component of Rumex roots, and its modes of action in vitro and in vivo. Biofactors. 2014 Jul-Aug;40(4):436-47. doi:10.1002/biof.1165. Epub 2014 Apr 23. PMID: 24756979.

Cheong SH, Furuhashi K, Ito K, Nagaoka M, Yonezawa T, Miura Y, Yagasaki K. Daidzein promotes glucose uptake through glucose transporter 4 translocation to plasma membrane in L6 myocytes and improves glucose homeostasis in Type 2 diabetic model mice. J Nutr Biochem. 2014 Feb;25(2):136-43. doi: 10.1016/j.jnutbio.2013.09.012. Epub 2013 Nov 6. PMID: 24445037.

Cheong SH, Furuhashi K, Ito K, Nagaoka M, Yonezawa T, Miura Y, Yagasaki K. Antihyperglycemic effect of equol, a daidzein derivative, in cultured L6 myocytes and ob/ob mice. Mol Nutr Food Res. 2014 Feb;58(2):267-77. doi: 10.1002/mnfr.201300272. Epub 2013 Sep 3. PMID: 24039053.

Iida K, Yonezawa T, Choi SS, Nagai K, Woo JT. Sodium dodecyl sulfate and sodium dodecyl benzenesulfonate are ligands for peroxisome proliferator-activated receptor γ. J Toxicol Sci. 2013;38(5):697-702. doi:10.2131/jts.38.697. PMID: 24025786.

Lee YS, Cha BY, Choi SS, Choi BK, Yonezawa T, Teruya T, Nagai K, Woo JT. Nobiletin improves obesity and insulin resistance in high-fat diet-induced obese mice. J Nutr Biochem. 2013 Jan;24(1):156-62. doi: 10.1016/j.jnutbio.2012.03.014. Epub 2012 Aug 13. PMID: 22898571.

Choi SS, Cha BY, Choi BK, Lee YS, Yonezawa T, Teruya T, Nagai K, Woo JT. Fargesin, a component of Flos Magnoliae, stimulates glucose uptake in L6 myotubes. J Nat Med. 2013 Apr;67(2):320-6. doi: 10.1007/s11418-012-0685-4. Epub 2012 Jul 12. PMID: 22791412.

Choi SS, Cha BY, Lee YS, Yonezawa T, Teruya T, Nagai K, Woo JT. Honokiol and magnolol stimulate glucose uptake by activating PI3K-dependent Akt in L6 myotubes. Biofactors. 2012 Sep-Oct;38(5):372-7. doi: 10.1002/biof.1029. Epub 2012 Jun 7. PMID: 22674833.

Lee YS, Cha BY, Choi SS, Harada Y, Choi BK, Yonezawa T, Teruya T, Nagai K, Woo JT. Fargesin improves lipid and glucose metabolism in 3T3-L1 adipocytes and high-fat diet-induced obese mice. Biofactors. 2012 Jul-Aug;38(4):300-8. doi:10.1002/biof.1022. Epub 2012 Jun 2. PMID: 22674784.

Asai M, Lee JW, Itakura Y, Choi BK, Yonezawa T, Teruya T, Cha BY, Ohnishi M, Yamaguchi A, Woo JT. Effects of veraguensin and galgravin on osteoclast differentiation and function. Cytotechnology. 2012 May;64(3):315-22. doi: 10.1007/s10616-011-9416-z. Epub 2012 Apr 24. PMID: 22526488; PMCID: PMC3386385.

Tanabe R, Cha BY, Ha BG, Yonezawa T, Nagai K, Woo JT, Yagasaki K. Detection of adiponectin and monocyte chemoattractant protein-1 using a calixcrown derivatives-coated protein chip. J Immunoassay Immunochem. 2012;33(2):166-79. doi: 10.1080/15321819.2011.615360. PMID: 22471607.

Ha BG, Nagaoka M, Yonezawa T, Tanabe R, Woo JT, Kato H, Chung UI, Yagasaki K. Regulatory mechanism for the stimulatory action of genistein on glucose uptake in vitro and in vivo. J Nutr Biochem. 2012 May;23(5):501-9. doi:10.1016/j.jnutbio.2011.02.007. Epub 2011 Jun 17. PMID: 21684132.

Yonezawa T, Mase N, Sasaki H, Teruya T, Hasegawa S, Cha BY, Yagasaki K, Suenaga K, Nagai K, Woo JT. Biselyngbyaside, isolated from marine cyanobacteria, inhibits osteoclastogenesis and induces apoptosis in mature osteoclasts. J Cell Biochem. 2012 Feb;113(2):440-8. doi: 10.1002/jcb.23213. PMID: 21678460.

Lee JW, Iwahashi A, Hasegawa S, Yonezawa T, Jeon WB, Cha BY, Nagai K, Woo JT. Coptisine inhibits RANKL-induced NF-κB phosphorylation in osteoclast precursors and suppresses function through the regulation of RANKL and OPG gene expression in osteoblastic cells. J Nat Med. 2012 Jan;66(1):8-16. doi:10.1007/s11418-011-0537-7. Epub 2011 Jun 9. PMID: 21656335.

Yonezawa T, Lee JW, Hibino A, Asai M, Hojo H, Cha BY, Teruya T, Nagai K, Chung UI, Yagasaki K, Woo JT. Harmine promotes osteoblast differentiation through bone morphogenetic protein signaling. Biochem Biophys Res Commun. 2011 Jun 3;409(2):260-5. doi: 10.1016/j.bbrc.2011.05.001. Epub 2011 May 6. PMID: 21570953.

Yonezawa T, Lee JW, Akazawa H, Inagaki M, Cha BY, Nagai K, Yagasaki K, Akihisa T, Woo JT. Osteogenic activity of diphenyl ether-type cyclic diarylheptanoids derived from Acer nikoense. Bioorg Med Chem Lett. 2011 Jun 1;21(11):3248-51. doi: 10.1016/j.bmcl.2011.04.041. Epub 2011 Apr 17. PMID: 21550801.

Choi SS, Cha BY, Iida K, Sato M, Lee YS, Teruya T, Yonezawa T, Nagai K, Woo JT. Honokiol enhances adipocyte differentiation by potentiating insulin signaling in 3T3-L1 preadipocytes. J Nat Med. 2011 Jul;65(3-4):424-30. doi: 10.1007/s11418-011-0512-3. Epub 2011 Feb 16. PMID: 21327521.

Kihara T, Ichikawa S, Yonezawa T, Lee JW, Akihisa T, Woo JT, Michi Y, Amagasa T, Yamaguchi A. Acerogenin A, a natural compound isolated from Acer nikoense Maxim, stimulates osteoblast differentiation through bone morphogenetic protein action. Biochem Biophys Res Commun. 2011 Mar 11;406(2):211-7. doi: 10.1016/j.bbrc.2011.02.017. Epub 2011 Feb 15. PMID: 21303661.

Choi SS, Cha BY, Kagami I, Lee YS, Sasaki H, Suenaga K, Teruya T, Yonezawa T, Nagai K, Woo JT. N,N'-diphenethylurea isolated from Okinawan ascidian Didemnum molle enhances adipocyte differentiation in 3T3-L1 cells. J Antibiot (Tokyo). 2011 Mar;64(3):277-80. doi: 10.1038/ja.2010.168. Epub 2011 Jan 19. PMID: 21245869.

Choi SS, Cha BY, Iida K, Lee YS, Yonezawa T, Teruya T, Nagai K, Woo JT. Artepillin C, as a PPARγ ligand, enhances adipocyte differentiation and glucose uptake in 3T3-L1 cells. Biochem Pharmacol. 2011 Apr 1;81(7):925-33. doi: 10.1016/j.bcp.2011.01.002. Epub 2011 Jan 8. PMID: 21219874.

Lee YS, Cha BY, Saito K, Choi SS, Wang XX, Choi BK, Yonezawa T, Teruya T, Nagai K, Woo JT. Effects of a Citrus depressa Hayata (shiikuwasa) extract on obesity in high-fat diet-induced obese mice. Phytomedicine. 2011 Jun 15;18(8-9):648-54. doi: 10.1016/j.phymed.2010.11.005. Epub 2011 Jan 7. PMID: 21216135.

Yonezawa T, Hasegawa S, Asai M, Ninomiya T, Sasaki T, Cha BY, Teruya T, Ozawa H, Yagasaki K, Nagai K, Woo JT. Harmine, a β-carboline alkaloid, inhibits osteoclast differentiation and bone resorption in vitro and in vivo. Eur J Pharmacol. 2011 Jan 15;650(2-3):511-8. doi: 10.1016/j.ejphar.2010.10.048. Epub 2010 Nov 1. PMID: 21047508.

Lee JW, Mase N, Yonezawa T, Seo HJ, Jeon WB, Cha BY, Nagai K, Woo JT. Palmatine attenuates osteoclast differentiation and function through inhibition of receptor activator of nuclear factor-κb ligand expression in osteoblast cells. Biol Pharm Bull. 2010;33(10):1733-9. doi: 10.1248/bpb.33.1733. PMID: 20930384.

Lee YS, Cha BY, Yamaguchi K, Choi SS, Yonezawa T, Teruya T, Nagai K, Woo JT. Effects of Korean white ginseng extracts on obesity in high-fat diet-induced obese mice. Cytotechnology. 2010 Aug;62(4):367-76. doi: 10.1007/s10616-010-9288-7. Epub 2010 Sep 23. PMID: 20862608; PMCID: PMC2978305.

Lee JW, Kobayashi Y, Nakamichi Y, Udagawa N, Takahashi N, Im NK, Seo HJ, Jeon WB, Yonezawa T, Cha BY, Woo JT. Alisol-B, a novel phyto-steroid, suppresses the RANKL-induced osteoclast formation and prevents bone loss in mice. Biochem Pharmacol. 2010 Aug 1;80(3):352-61. doi: 10.1016/j.bcp.2010.04.014. Epub 2010 Apr 20. PMID: 20412788.

Hojo H, Yano F, Ohba S, Igawa K, Nakajima K, Komiyama Y, Kan A, Ikeda T, Yonezawa T, Woo JT, Takato T, Nakamura K, Kawaguchi H, Chung UI. Identification of oxytetracycline as a chondrogenic compound using a cell-based screening system. J Bone Miner Metab. 2010 Nov;28(6):627-33. doi: 10.1007/s00774-010-0179-y. Epub 2010 Apr 8. PMID: 20376510.

Tanabe R, Cha BY, Yonezawa T, Woo JT, Nagai K. [Highly sensitive method of detecting verotoxins produced by enterohaemorrhagic Escherichia coli O-157 : H7 using a protein chip]. Shokuhin Eiseigaku Zasshi. 2010;51(1):28-31. Japanese. doi: 10.3358/shokueishi.51.28. PMID: 20208406.

Hasegawa S, Yonezawa T, Ahn JY, Cha BY, Teruya T, Takami M, Yagasaki K, Nagai K, Woo JT. Honokiol inhibits osteoclast differentiation and function in vitro. Biol Pharm Bull. 2010;33(3):487-92. doi: 10.1248/bpb.33.487. PMID: 20190414.

Lee JW, Ahn JY, Hasegawa S, Cha BY, Yonezawa T, Nagai K, Seo HJ, Jeon WB, Woo JT. Inhibitory effect of luteolin on osteoclast differentiation and function. Cytotechnology. 2009 Dec;61(3):125-34. doi: 10.1007/s10616-010-9253-5. Epub 2010 Feb 17. PMID: 20162352; PMCID: PMC2825295.

Lee YS, Cha BY, Saito K, Yamakawa H, Choi SS, Yamaguchi K, Yonezawa T, Teruya T, Nagai K, Woo JT. Nobiletin improves hyperglycemia and insulin resistance in obese diabetic ob/ob mice. Biochem Pharmacol. 2010 Jun 1;79(11):1674-83. doi: 10.1016/j.bcp.2010.01.034. Epub 2010 Feb 6. PMID: 20144590.

Cha BY, Shi WL, Yonezawa T, Teruya T, Nagai K, Woo JT. An inhibitory effect of chrysoeriol on platelet-derived growth factor (PDGF)-induced proliferation and PDGF receptor signaling in human aortic smooth muscle cells. J Pharmacol Sci. 2009 May;110(1):105-10. doi: 10.1254/jphs.08282fp. Epub 2009 May 8. PMID: 19423953.

Choi SS, Cha BY, Lee YS, Yonezawa T, Teruya T, Nagai K, Woo JT. Magnolol enhances adipocyte differentiation and glucose uptake in 3T3-L1 cells. Life Sci. 2009 Jun 19;84(25-26):908-14. doi: 10.1016/j.lfs.2009.04.001. Epub 2009 Apr 17. PMID: 19376135.

Hojo H, Igawa K, Ohba S, Yano F, Nakajima K, Komiyama Y, Ikeda T, Lichtler AC, Woo JT, Yonezawa T, Takato T, Chung UI. Development of high-throughput screening system for osteogenic drugs using a cell-based sensor. Biochem Biophys Res Commun. 2008 Nov 14;376(2):375-9. doi: 10.1016/j.bbrc.2008.08.167. Epub 2008 Sep 20. PMID: 18789892.

Woo JT, Yonezawa T, Cha BY, Teruya T, Nagai K. Pharmacological topics of bone metabolism: antiresorptive microbial compounds that inhibit osteoclast differentiation, function, and survival. J Pharmacol Sci. 2008 Apr;106(4):547-54. doi: 10.1254/jphs.fm0070288. PMID: 18431038.

Yonezawa T, Hasegawa S, Ahn JY, Cha BY, Teruya T, Hagiwara H, Nagai K, Woo JT. Tributyltin and triphenyltin inhibit osteoclast differentiation through a retinoic acid receptor-dependent signaling pathway. Biochem Biophys Res Commun. 2007 Mar 30;355(1):10-5. doi: 10.1016/j.bbrc.2006.12.237. Epub 2007 Jan 22. PMID: 17291456.

Woo JT, Kawatani M, Kato M, Shinki T, Yonezawa T, Kanoh N, Nakagawa H, Takami M, Lee KH, Stern PH, Nagai K, Osada H. Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Proc Natl Acad Sci U S A. 2006 Mar 21;103(12):4729-34. doi: 10.1073/pnas.0505663103. Epub 2006 Mar 13. PMID: 16537392; PMCID: PMC1450238.

Akiyama S, Yonezawa T, Kudo TA, Li MG, Wang H, Ito M, Yoshioka K, Ninomiya-Tsuji J, Matsumoto K, Kanamaru R, Tamura S, Kobayashi T. Activation mechanism of c-Jun amino-terminal kinase in the course of neural differentiation of P19 embryonic carcinoma cells. J Biol Chem. 2004 Aug 27;279(35):36616-20. doi: 10.1074/jbc.M406610200. Epub 2004 Jun 24. PMID: 15218018.

Woo JT, Nakagawa H, Notoya M, Yonezawa T, Udagawa N, Lee IS, Ohnishi M, Hagiwara H, Nagai K. Quercetin suppresses bone resorption by inhibiting the differentiation and activation of osteoclasts. Biol Pharm Bull. 2004 Apr;27(4):504-9. doi: 10.1248/bpb.27.504. PMID: 15056855.

Tamura S, Hanada M, Sasaki M, Komaki K, Yonezawa T, Kobayashi T. [Regulation of stress-activated protein kinase signaling pathways by protein phosphatases]. Tanpakushitsu Kakusan Koso. 2002 Apr;47(5):568-75. Japanese. PMID: 11974854.

Yamaki K, Yonezawa T, Ohuchi K. Signal transduction cascade in staurosporine-induced prostaglandin E(2) production by rat peritoneal macrophages. J Pharmacol Exp Ther. 2000 Apr;293(1):206-13. PMID: 10734171.

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