CHUBU UNIVERSITY
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TSUTSUMIUCHI Kaname

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Year of Birth 1970
Place of Birth Tokoname, Aichi
Title Professor
Belong to Dept. of Biological Chemistry
Bioscience and Biotechnology (graduate school)
Division of University Evaluation
Graduated Nagoya University, Graduate School of Agriculture
Degree Dr. of Agriculture, Nagoya University
Academic Institutional Membership The Society of Polymer Science Japan
The Chemical Society of Japan
The Japan Society for Analytical Chemistry
Japanese Society for Food Hygiene and Safety
The Society of Synthetic Organic Chemistry, Japan
The Japanese Society of Carbohydrate Research
The Japanese Society of Applied Glycoscience
The Cellulose Society of Japan
Japanese Society for Medical Use of Functional Foods
Japanese Society for Biomedical Mass Spectrometry
Japanese Society of Food Chemistry
Japanese Society for Thermal Medicine
Field of Study Polymer Chemistry, Organic Chemistry, Analytical Chemistry
Research, Studies Preparation of Magnetic Nanoparticles for Active Targeting; Chemical Synthesis of (1->3)-β-D-Glucan, Deuteration of Biofunctional Compounds by H-D Exchange Reaction and Their Application
Curriculum Specialized Organic Chemistry 1, Organic Chemistry 2, Organic Chemistry Laboratory

Books Published, Translation

Chapter 7 Chemical Reactions: Energy, Rates, and Equilibrium (translator), Japanese Language Edition of Fundamentals of General, Organic, and Biological Chemistry, 7th Edition by John McMurry, Maruzen, 2015

Acrylamide (author), Encyclopedia of Food Safety, ed. Japanese Society for Food Hygiene and Safety, Asakura Publishing, 2009

Chapter 7 Chemical Reactions: Energy, Rates, and Equilibrium (translator), Japanese Language Edition of Fundamentals of General, Organic, and Biological Chemistry, 5th Edition by John McMurry, Maruzen, 2007

Syntheses and Functions of Glycopeptide Surface-Modified Dendrimers (coauthor), Tailored Polymers & Applications, VSP, 2000

Academic Papers, Critique

Identification of evodiamine in the microalga Dunaliella tertiolecta (Chlorophyceae), S. Sakaki, K. Tsutsumiuchi, Y. Yamaguchi, H. Yamashita, H. Takenaka, New Food Industry, 60, 13-18 (2018).

Chemical synthesis of 6 -and 7-phosphono metylnapthalene-1-carboxylic acids, M. Kawamura, M. Ohnishi, K. Tsutsumiuchi, Annual Report of Research Institute for Biological Function, 18, 62-69 (2018).

Analysis of gardenia blue in foods by thin-layer chromatography, S. Matsuyama, H. Oka, K. Furuya, T. Morimoto, K. Tsutsumiuchi, Journal of Liquid Chromatography & Related Technologies, 41, 83-86 (2018).

Effect of crystal status transformation on the thermal shrinkage characteristics and extensional characteristics of acetaldehyde solvent-induced crystalization PET film, M. Ishinabe, Y. Yamashita, K. Tsutsumiuchi, K. Tashiro, K. Imaeda, M. Kawamura, Transactions of the Materials Research Society of Japan, 42, 107-111 (2017).

Safety of Regional 8-MHz Radiofrequency Capacitive Hyperthermia Combined with Magnetic Cationic Liposomes in Patients with Castration-Resistant Prostate Cancer: A Phase I Clinical Study, N. Kawai, T. Kobayashi, D. Kobayashi, K. Tsutsumiuchi, K. Iida, T. Etani, T. Naiki, R. Ando, K. Mizuno, A. Okada, K. Tozawa, T. Yasui, Journal of International Translational Medicine, 4, 258-267 (2016).

H. Yamashita, T. Kusudo, T. Takeuchi, S. Qiao, K. Tsutsumiuchi, T. Wang, Y. Wang, Dietary supplementation with evodiamine prevents age-associated obesity and improves insulin resistance in mice, Journal of Functional Foods, 19, 320-329 (2015).

K. Arai, H. Terashima, S. Aizawa, A. Taga, A. Yamamoto, K. Tsutsumiuchi, S. Kodama, Simultaneous Determination of Trigonelline, Caffeine, Chlorogenic Acid and Their Related Compounds in Instant Coffee Samples by HPLC Using an Acidic Mobile Phase Containing Octanesulfonate, Analytical Sciences, 31(8), 831-835 (2015).

K. Inoue, D. Hosaka, N. Mochizuki, H. Akatsu, K. Tsutsumiuchi, Y. Hashizume, N. Matsukawa, T. Yamamoto, T. Toyo'oka, Simultaneous Determination of Post-Translational Racemization and Isomerization of N‑Terminal Amyloid‑β in Alzheimer’s Brain Tissues by Covalent Chiral Derivatized Ultraperformance Liquid Chromatography Tandem Mass Spectrometry, Analytical Chemistry, 86 (1), 797-804 (2014).

H. Takahashi, R. Nakayama, S. Hayashi, T. Nemoto, Y. Murase, K. Nomura, T. Takahashi, K. Kubo, S. Marui, K. Yasuhara, T. Nakamura, T. Sueno, A. Takahashi, K. Tsutsumiuchi, T. Ohta, A. Kawai, S. Sugita, S. Yamamoto, T. Honda, T. Yoshida, T. Hasegawa, Macrophage Migration Inhibitory Factor and Stearoyl-CoA Desaturase 1: Potential Prognostic Markers for Soft Tissue Sarcomas Based on Bioinformatics Analyses, PLoS One, 8 (10), e78250 (2013).

M. Yamashiro, T. Sugimura, T. Kobayashi, K. Tsutsumiuchi, Preparation and characterization of N-vinyl-2-pyrroridone-methyl methacrylate-methacrylic acid terpolymer-coated magnetite nanoparticles, Kobunshi Ronbunshu, 69(7), 392-398(2012).

K. Inoue, A. Ikemura, Y. Tsuruta, K. Tsutsumiuchi, T. Hino, and H. Oka, On-line solid phase extraction LC-MS/MS for the determination of Ac-SDKP peptide in human plasma from hemodialysis patients, Biomedical Chromatography, 26 (2), 137-141 (2012).

K. Tsutsumiuchi, Y. Watanabe, M. Watanabe, M. Hibino, M. Kambe, N. Okajima, H. Negishi, J. Miwa, and H. Taniguchi, Formation of acrylamide from glucans and asparagine, New Biotechnology, 28 (6), 566-573 (2011).

K. Inoue, A. Ikemura, Y. Tsuruta, K. Watanabe, K. Tsutsumiuchi, T. Hino, and H. Oka, Quantification of N-acetyl-seryl-aspartyl-lysyl-proline in hemodialysis patients administered angiotensin-converting enzyme inhibitors by stable isotope dilution liquid chromatography–tandem mass spectrometry, Journal of Pharmaceutical and Biomedical Analysis, 54 (4), 765-771 (2011).

K. Inoue, Y. Ito, Y. Hattori, K. Tsutsumiuchi, S. Ito, T. Hino, H. Oka, Efficient purification of xanthomonasin A and B from Monascus yellow colorant by high-speed countercurrent chromatography, Japanese Journal of Food Chemistry and Safety, 17 (3), 185-191 (2010).

K. Hasegawa, S. Miwa, K. Tsutsumiuchi, J. Miwa, Allyl Isothiocyanate That Induces GST and UGT Expression Confers Oxidative Stress Resistance on C. elegans, as Demonstrated by Nematode Biosensor, PLoS ONE, 5 (2), e9267 (2010).

K. Tsutsumiuchi, "Acrylamide" in Encyclopedia of Food Safety, ed. Japanese Society for Food Hygiene and Safety, Asakura Publishing, 2009, p.229-231.

K. Inoue, Y. Mizuno, Y. Yoshimi, M. Nunome, T. Hino, K. Tsutsumiuchi, H. Oka, Determination of avoparcin in animal tissues and milk using LC-ESI-MS/MS and tandem-SPE, Journal of Separation Science, 31 (22), 3871-3878 (2008).

K. Inoue, C. Nomura, Y. Mizuno, Y. Yoshimi, K. Tsutsumiuchi, T. Hino, H. Oka, Separation of Major Safflowers from Carthamus Yellow using High-Speed Countercurrent Chromatography, Journal of Liquid Chromatography & Related Technologies, 31 (7), 1047-1059 (2008).

K. Hasegawa, S. Miwa, K. Isomura, K. Tsutsumiuchi, H. Taniguchi, J. Miwa, Acrylamide-Responsive Genes in the Nematode Caenorhabditis elegans, Toxicological Sciences, 101 (2), 215-225 (2008).

K. Hasegawa, S. Miwa, T. Tajima, K. Tsutsumiuchi, H. Taniguchi, J. Miwa, A Rapid Inexpensive Method to Screen for Common Foods That Reduce the Action of Acrylamide, a Harmful Substance in Food, Toxicology Letters, 175 (1-3), 82-88 (2007).

K. Tsutsumiuchi, M. Kambe, N. Okajima, M. Takamura, M. Okada, J. Miwa, H. Taniguchi, Acrylamide in Foods, Annual Report of Research Institute for Biological Function (Chubu University), 7, 7-12 (2007).

K. Tsutsumiuchi, Methods for reducing the levels of acrylamide monomer in processed foods, Journal of the Food Hygienics Society of Japan, 46 (6), J-335-J-337 (2005).

K. Tsutsumiuchi, M. Hibino, M. Kambe, N. Okajima, M. Okada, J. Miwa, and H. Taniguchi, Effect of Carbohydrates on Formation of Acrylamide in Cooked Food Models, Journal of Applied Glycoscience, 52 (3), 219-224 (2005).

K. Hasegawa, S. Miwa, K. Tsutsumiuchi, H. Taniguchi, and J. Miwa, Extremely Low Dose of Acrylamide Decreases Lifespan in Caenorhabditis elegans, Toxicology Letters, 152 (2), 183-189 (2004).

K. Tsutsumiuchi, Synthesis of Allyl 3-O-Allyl-6-O-(p-methoxyphenyl)-D-glucopyranoside, Annual report of College of Bioscience and Biotechnology (Chubu University), 3, 5-8(2004).

K. Tsutsumiuchi, M. Hibino, M. Kambe, K. Oishi, M. Okada, J. Miwa, and H. Taniguchi, Application of Ion-trap LC/MS/MS for Determination of Acrylamide in Processed Foods, Journal of the Food Hygienics Society of Japan, 45 (2), 95-99 (2004).

K. Funayama, T. Imae, K. Aoi, K. Tsutsumiuchi, M. Okada, M. Furusaka, and M. Nagao, Small-Angle Neutron Scattering Investigations of Layer-Block Dendrimers in Aqueous Solutions, The Journal of Physical Chemistry B, 107 (7), 1532-1539 (2003).

K. Funayama, T. Imae, H. Seto, K. Aoi, K. Tsutsumiuchi, M. Okada, M. Nagao, and M. Furusaka, Fast and Slow Dynamics of Water-Soluble Dendrimers Consisting of Amido-Amine Repeating Units by Neutron Spin-Echo, The Journal of Physical Chemistry B, 107 (6), 1353-1359 (2003).

M. Ito, T. Imae, K. Aoi, K. Tsutsumiuchi, H. Noda, and M. Okada, In Situ Investigation of Adlayer Formation and Adsorption Kinetics of Amphiphilic Surface-Block Dendrimers on Solid Substrates, Langmuir, 18 (25), 9757-9764 (2002).

K. Aoi, M. Katsube, K. Tsutsumiuchi, M. Okada, Controlled Architecture of Nano-Structures Based on Star Dendrimers, Kobunshi Ronbunshu, 59(12), 742-752 (2002).

K. Tsutsumiuchi, Improved Synthesis of 3-O-Acetyl-2,4,6-Tri-O-Benzyl-α-D-Glucopyranosyl Chloride from Allyl 3-O-Allyl-2,4,6-Tri-O-Benzyl-D-Glucopyranoside, Annual Report of Research Institute for Biological Function (Chubu University), 2, 17-20 (2002).

K. Funayama, T. Imae, K. Aoi, K. Tsutsumiuchi, M. Okada, H. Seto, and M. Nagao, Characterizations of Sugar Ball in Solution by SANS and NSE, Journal of Physical Society Japan, 70 (Supplement A), 326-328 (2001).

K. Funayama, T. Imae, K. Aoi, K. Tsutsumiuchi, M. Okada, and H. Seto, Dynamics of Poly(amido amine) Dendrimer in Aqueous Solutions, Activity Report on Neutron Scattering Research, 2000, 266 (2001).

K. Funayama, T. Imae, K. Aoi, K. Tsutsumiuchi, M. Okada, and M. Nagao, Conformation of Sugar Ball in Aqueous Solutions, Activity Report on Neutron Scattering Research, 2000, 261 (2001).

T. Imae, M. Ito, K. Aoi, K. Tsutsumiuchi, H. Noda, and M. Okada, Formation of Organaized Adsorption Layers by Amphiphilic Dendrimers, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 175 (1-2), 225-234 (2000).

K. Funayama, T. Imae, K. Aoi, K. Tsutsumiuchi, M. Okada, and M. Furusaka, Segment Density Profiles in Dendrimers by SANS Analysis, KENS Report, 12, 219-220 (2000).

K. Aoi,T. Hatanaka, K. Tsutsumiuchi, M. Okada, and T. Imae, SANS Analysis of a Novel Star-Shaped Dendrimer, KENS Report, 12, 217-218 (2000).

M. Okada, K. Aoi, and K. Tsutsumiuchi, "Syntheses and Functions of Glycopeptide Surface-Modified Dendrimers" in Tailored Polymers & Applications, Y. Yagci, M. K. Mishra, O. Nuyken, K. Ito, and G. Wnek, Eds., VSP, Zeist, 2000, p.85-96.

K. Tsutsumiuchi, K. Aoi, and M. Okada, Ion Complex Formation between Poly(amido amine) Dendrimer HCI Salt and Poly(L-glutamic acid) Sodium Salt, Polymer Journal, 32 (2), 107-112 (2000).

K. Aoi, A. Motoda, M. Ohno, K. Tsutsumiuchi, M. Okada, and T. Imae, Synthesis and Assembly of Amphiphilic Tadpole-Shaped Block Copolymers Based on Poly(amido amine) Dendrimer, Polymer Journal, 31 (11-2), 1071-1078 (1999).

K. Tsutsumiuchi, K. Aoi, and M. Okada, Globular Carbohydrate Macromolecule" Sugar Balls" 4. Synthesis of Dendritic Nanocapsules with Molecular Recognition Sites on Periphery, Polymer Journal, 31 (11-1), 935-941 (1999).

K. Aoi, T. Hatanaka, K. Tsutsumiuchi, M, Okada, and T. Imae, Synthesis of a Novel Star-Shaped Dendrimer by Radial-Growth Polymerization of Sarcosine Ν-Carboxyanhydride Initiated with Poly(trimethyleneimine) Dendrimer, Macromolecular Rapid Communication, 20 (7), 378-382 (1999).

T. Imae, K. Funayama, K. Aoi, K. Tsutsumiuchi, M. Okada, M. Furusaka, Small-Angle Neutron Scattering and Surface Force Investigations of Poly(amido amine) Dendrimer with Hydroxyl End Groups, Langmuir, 15 (12), 4076-4084 (1999).

T. Imae, K. Funayama, K. Aoi, K. Tsutsumiuchi, and M. Okada, Intermolecular Interaction and Adsorption Properties of Poly(amido amine) Dendrimer with OH-Terminal, Proceedings of Yamada Conference L Polyelectrolytes, 439-442 (1999).

K. Aoi, K. Tsutsumiuchi, A. Yamamoto, and M. Okada, Globular Carbohydrate Macromolecule "Sugar Balls" 2. Synthesis of Mono(glycopeptide)-Persubstituted Dendrimers by Polymer Reaction with Sugar-Substituted α-Amino Acid Ν-Carboxyanhydrides (glycoNCAs), Macromolecular Rapid Communication, 19 (1), 5-9 (1998).

M. Okada, K. Aoi, and K. Tsutsumiuchi, Synthesis of Glycopeptide Conjugates via Ring-Opening Polymerization of Sugar-Substituted α-Amino Acid Ν-Carboxyanhydrides (GlycoNCAs), Proceedings of the Japan Academy, 73 (10), 205-209 (1997).

K. Aoi, K. Tsutsumiuchi, M. Okada, Archtectural Control of Carbohydrate Macromolecules Based on Sugar Balls and Living Glycopeptides, Kobunshi Ronbunshu, 54(10), 649-660 (1997).

K. Aoi, K. Tsutsumiuchi, A. Yamamoto, and M. Okada, Globular Carbohydrate Macromolecule "Sugar Balls" 3. "Radial-Growth Polymerization"of Sugar-Substituted α-Amino Acid Ν-Carboxyanhydrides (GlycoNCAs) with a Dendritic Initiator, Tetrahedron, 53 (45), 15415-15427 (1997).

K. Tsutsumiuchi, K. Aoi, and M. Okada, Synthesis of Polyoxazoline-(Glyco)peptide Block Copolymers by Ring-Opening Polymerization of (Sugar-Substituted) α-Amino Acid Ν-Carboxyanhydrides with Polyoxazoline Macroinitiators, Macromolecules, 30 (14), 4013-4017 (1997).

K. Naka, R. Yamashita, T. Nakamura, A. Ohki, S. Maeda, K. Aoi, K. Tsutsumiuchi, and M. Okada, Aggregates of Peptide Containing Block Copolymers and Their Interactions with a Lipase in Aqueous Solution, Macromolecular Chemistry and Physics, 198 (1), 89-100 (1997).

K. Aoi, K. Tsutsumiuchi, E. Aoki, and M. Okada, First Synthesis of Glycopeptide Macromonomers and Graft-Type Sugar-Containing Polymers with Glycopeptide Side Chains, Macromolecules, 29 (12), 4456-4458 (1996).

K Naka, R. Yamashita, T. Nakamura, A. Ohki, S. Maeda, K. Aoi, K. Tsutsumiuchi, and M. Okada, Aggregate of a Peptide-Containing Block Copolymer with a Lipase, Macromolecular Rapid Communication, 17 (4), 269-274 (1996).

K. Aoi, K. Tsutsumiuchi, and M. Okada, Synthesis of Novel Glycopeptide-Polyoxazoline Block Copolymers by Direct Coupling between Living Anionic and Cationic Polymerization Systems, Macromolecular Rapid Communication, 16 (10), 749-755 (1995).

K. Aoi, K. Tsutsumiuchi, and M. Okada, Glycopeptide Synthesis by an α-Amino Acid Ν-Carboxyanhydride (NCA) Method: Ring-Opening Polymerization of a Sugar-Substituted NCA, Macromolecules, 27 (3), 875-877 (1994).

Awards

Award for Encouragement of Research in Polymer Science, the Society of Polymer Science, Japan (2004)

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