CHUBU UNIVERSITY
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SHIMOMURA Yoshiharu

Profile

Year of Birth 1953
Place of Birth Aichi
Title Professor
Belong to Dept. of Food and Nutritional Sciences
Center for Registered Dietitian Practicum Support
Bioscience and Biotechnology (graduate school)
Graduated Nagoya University Graduate School of Medicine
Degree Ph.D.
Academic Institutional Membership Japan Society of Nutrition and Food Science, Advisor (President 2016-2017)
Japanese Society for Amino Acid Sciences, Advisor (President 2011-2014)
Field of Study Nutritional Biochemistry
Research, Studies Regulation of branched-chain amino acid (BCAA) catabolism and physiological functions of BCAA
Curriculum Specialized Branched-chain amino acids, fructooligosaccharides

Academic Papers, Critique

Ca2+-dependent inhibition of branched-chain α-ketoacid dehydrogenase kinase by thiamine pyrophosphate. Biochem Biophys Res Commun. 2018 Oct 12;504(4):916-920. doi: 10.1016/j.bbrc.2018.09.038.

Physiological and pathological roles of branched-chain amino acids in the regulation of protein and energy metabolism and neurological functions. Pharmacol Res. 2018 Jul;133:215-217. doi: 10.1016/j.phrs.2018.05.014.

Branched-chain amino acid (BCAA) supplementation enhances adaptability to exercise training of mice with a muscle-specific defect in the control of BCAA catabolism. Biosci Biotechnol Biochem. 2018 Mar 1:1-4. doi: 10.1080/09168451.2018.1440174.

Endurance performance and energy metabolism during exercise in mice with a muscle-specific defect in the control of branched-chain amino acid catabolism. PLoS One. 2017 Jul 18;12(7):e0180989. doi: 10.1371/journal.pone.0180989.

Branched-chain amino acids alleviate hepatic steatosis and liver injury in choline-deficient high-fat diet induced NASH mice. Metabolism, 2017, 69:177-187. doi: 10.1016/j.metabol.2016.12.013.

Muscle-specific deletion of BDK amplifies loss of myofibrillar protein during protein undernutrition. Sci Rep. 2017 Jan 4;7:39825. doi: 10.1038/srep39825.

An alteration in the cecal microbiota composition by feeding of 1-kestose results in a marked increase in the cecal butyrate content in rats. PLoS One. 2016 Nov 18;11(11):e0166850. doi: 10.1371/journal.pone.0166850.

Clinical, biochemical, and metabolic characterization of a mild form of human short-chain enoyl-CoA hydratase deficiency: significance of increased N-acetyl-S-(2-carboxypropyl)cysteine excretion. J Med Genet. 52(10): 691-698. doi: 10.1136/jmedgenet-2015-103231.

Octanoic acid promotes branched-chain amino acid catabolism via the inhibition of hepatic branched-chain alpha-keto acid dehydrogenase kinase in rats. Metabolism. 64(9):1157-1164. doi: 10.1016/j.metabol.2015.05.014.

Clinical and biochemical characterization of 3-hydroxyisobutyryl-CoA hydrolase (HIBCH) deficiency that causes Leigh-like disease and ketoacidosis. Mol Genet Metab Rep. 2014 Oct 16;1:455-460. eCollection 2014.

Awards

Japan Society of Nutrition and Food Science (JSNFS) Award for Excellence in Research (2011)

Ajinomoto Award for BCAA Basic Research (2001)

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