CHUBU UNIVERSITY
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YOSHIMURA Kazuya

Profile

Title Associate Professor
Belong to Dept. of Food and Nutritional Sciences
Bioscience and Biotechnology (graduate school)
Center for Registered Dietitian Practicum Support
Graduated Kinki university, Graduate School of Agriculture
Degree Ph.D
Qualification Biochemistry
Academic Institutional Membership The Molecular Biology Society of Japan
Japan Society for Bioscience Biotechnology, and Agrochemistry
The Japanese Society of Plant Physiologists
The Vitamin society of Japan
Euglena Research Association
Field of Study Molecular Biology, Biochemistry, Plant Physiology
Research, Studies Analysis of redox regulation and oxidative stress defense mechanisms in higher plants

Books Published, Translation

4. Ishikawa T., Maruta T., Yoshimura K., Smirnoff N. Biosynthesis and regulation of ascorbic acid in plants. In: Gupta D., Palma J., Corpas F. (Eds.) Antioxidants and Antioxidant Enzymes in Higher Plants. Springer International Publishing, p163-179, 2018

3. Yoshimura, K., Ishikawa, T. Chemistry and metabolism of ascorbic acid in plants. In: Hossain MA, Munné-Bosch S, Burritt DJ, Vivancos PD, Fujita M, Lorence A (Eds.) Ascorbic Acid in Plant Growth, Development and Stress Tolerance. Springer International Publishing, p1-23, 2018

2. Watanabe, F., Yoshimura, K., Shigeoka, S. Biochemistry and Physiology of Vitamins in Euglena. In: Euglena: Biochemistry, Cell and Molecular Biology. Schwartzbach, S.D. and Shigeoka, S. (Eds.), Advances in Experimental Medicine and Biology. Volume 979, Springer, p65-85, 2017

1. Ishikawa, T., Maruta, T., Ogawa, T., Yoshimura, K., Shigeoka, S. Redox balance in chloroplasts as a modulator of environmental stress responses: The role of ascorbate peroxidase and Nudix hydrolase in Arabidopsis. In: Redox State as a Central Regulator of Plant-Cell Stress Responses. Gupta, D.K., Palma, J.M., Corpas F.J. (Eds.) Springer International Publishing, p51-70, 2016

Academic Papers, Critique

Publication

58. Ogawa T, Yoshimura K. Modulation of the subcellular levels of redox cofactors by Nudix hydrolases in chloroplasts. Environ. Exp. Bot. 2018 in press

57. Maruta, T., Ogawa, T., Tsujimura, M., Ikemoto, K., Yoshida, T., Takahashi, H., Yoshimura, K., Shigeoka, S. Loss-of-function of an Arabidopsis NADPH pyrophosphohydrolase, AtNUDX19, impacts on the pyridine nucleotides status and confers photooxidative stress tolerance. Sci. Rep., 6, 37432, 2016

56. Akashi, K.*, Yoshimura, K.*, Kajikawa, M., Hanada, K., Kosaka, R., Kat,o A., Katoh, A., Nanasato, Y., Tsujimoto, H., Yokota, A. *These authors contributed equally to this work. Potential involvement of drought-induced Ran GTPase CLRan1 in root growth enhancement in a xerophyte wild watermelon. Biosci. Biotechnol. Biochem. 80, 1907-1916, 2016

55. Ogawa, T., Muramoto, K., Takada, R., Nakagawa, S., Shigeoka, S., Yoshimura, K. Transient expression analysis revealed the distinct roles of Arabisopsis Nudix hydrolases, AtNUDX6 and 7, in various cellular responses involved in biotic/abiotic stresses. Plant Cell Physiol. 57, 1295-1308, 2016

54. Corpas, F.J., Aguayo-Trinidad, S., Ogawa, T., Yoshimura, K., Shigeoka, S. Activation of NADPH-recycling systems in leaves and roots of Arabidopsis thaliana under arsenic-induced stress conditions is accelerated by knock-out of Nudix hydrolase 19 (AtNUDX19) gene. J. Plant Physiol., 192, 81-89, 2016

53. Tanaka, H., Maruta, T., Ogawa, T., Tanabe, N., Tamoi, M., Yoshimura, K., and Shigeoka, S. Identification and characterization of the first member of an Arabidopsis GDP-D-mannose pyrophosphohydrolase, AtNUDX9: its involvement in the regulation of GDP-D-mannose metabolism. J. Exp. Bot., 66, 5797-5808, 2015

52. Yoshimura, K. and Shigeoka, S. (Award review) Versatile physiological functions of the Nudix hydrolase family in Arabidopsis. Biosci. Biotechnol. Biochem. 79, 354-366, 2015

51. Maruta, T., Miyazaki, N., Nosaka, R., Tanaka, H., Padilla-Chacon, D., Otori, K., Kimura, A., Tanabe, N., Yoshimura, K., Tamoi, M., and Shigeoka, S. A gain-of-function mutation of plastidic invertase alters nuclear gene expression with sucrose treatment partially via GENOMES UNCOUPLED1-mediated signaling. New Phytologist 206, 1013-1023, 2015

50. Tanaka, H., Maruta, T., Tamoi, M., Yabuta, Y., Yoshimura K., Ishikawa, T., and Shigeoka, S. Transcriptional control of Vitamin C defective 2 and Tocopherol cyclase genes by light and plastid-derived signals: the partial involvement of GENOMES UNCOUPLED 1. Plant Sci. 231, 20-29, 2015

49. Yoshimura, K., Ogawa, T., Tsujimura, M., Ishikawa, K., Shigeoka, S. Ectopic Expression of the Human MutT-Type Nudix Hydrolase, hMTH1, Confers Enhanced Tolerance to Oxidative Stress in Arabidopsis. Plant Cell Physiol. 55, 1534-1543, 2014

48. Yoshimura, K., Nakane, T., Kume, S., Shiomi, Y., Maruta, T., Ishikawa, T., Shigeoka, S. Transient expression analysis reveals importance of VTC2 expression level in light/dark regulation of ascorbate biosynthesis in Arabidopsis. Bioscience, Biotechnology, and Biochemistry 78, 60-66, 2014

47. Ito, D., Kato, T., Maruta, T., Tamoi, M., Yoshimura, K., and Shigeoka, S. Enzymatic and molecular characterization of Arabidopsis ppGpp pyrophosphohydrolase, AtNUDX26. Bioscience, Biotechnology, and Biochemistry 76, 120523-120526, 2012

46. Mori, T.*, Yoshimura, K.*, Nosaka, R., Sakuyama, H., Koike, Y., Tanabe, N., Maruta, T., Tamoi, M., and Shigeoka, S. Subcellular and subnuclear distribution of high-light responsive serine/arginine-rich proteins, atSR45a and atSR30, in Arabidopsis thaliana. Bioscience, Biotechnology, and Biochemistry 76, 120425-120431 *These authors contributed equally to this work.

45. Maruta, T., Inoue, T., Noshi, M., Tamoi, M., Yabuta, Y., Yoshimura, K., Ishikawa, T., and Shigeoka, S. Cytosolic ascorbate peroxidase 1 protects organelles against oxidative stress by wounding- and jasmonate-induced H2O2 in Arabidopsis plants. Biochimica et Biophysica Acta 1820, 1901-1907, 2012

44. Gaber, A., Ogata, T., Maruta, T., Yoshimura, K., Tamoi, M., and Shigeoka, S. The involvement of Arabidopsis glutathione peroxidase 8 in the suppression of oxidative damages in nucleus and cytosol. Plant Cell Physiology 53, 1596-1606, 2012

43. Maruta, T., Yoshimoto, T., Ito, D., Ogawa, T., Tamoi, M., Yoshimura, K., Shigeoka, S. An Arabidopsis FAD pyrophosphohydrolase, AtNUDX23, is involved in the flavin homeostasis. Plant Cell Physiology 53, 1106-1116, 2012

42. Maruta, T., Noshi, M., Tanouchi, A., Tamoi, M., Yabuta, Y., Yoshimura, K., Ishikawa, T., and

Shigeoka, S. H2O2-triggered retrograde signaling from chloroplasts to nucleus plays a specific role in the response to stress. Journal of Biological Chemistry 287, 11717-11729, 2012

41. Ito, D., Yoshimura, K., Ishikawa, K., Ogawa, T., Maruta, T., Shigeoka, S. Comparative analysis of molecular characteristics of Arabidopsis CoA pyrophosphohydrolases, AtNUDX11, 15, and 15a. Bioscience, Biotechnology, and Biochemistry 76, 139-147, 2012

40. Yoshimura, K., Mori, T., Yokoyama, K., Koike, Y., Tanabe, Y., Sato, N., Takahashi, H., Maruta, T., Shigeoka, S. Identification of alternative splicing events regulated by an Arabidopsis serine/arginine-like protein, atSR45a, in response to high-light stress using a tiling array. Plant Cell Physiology 52, 1786-1805, 2011

39. Nishizawa-Yokoi A., Nosaka R., Hayashi H., Tainaka H., Maruta, T., Tamoi M., Ikeda M., Ohme-Takagi M., Yoshimura K., Yabuta Y. and Shigeoka S. HsfA1d and HsfA1e involved in the transcriptional regulation of HsfA2 function as key regulators for Hsf signaling network in response to environmental stress. Plant Cell Physiology 52, 933–945, 2011

38. Maruta, T., Inoue, T., Tamoi, M., Yabuta, Y., Yoshimura, K., Ishikawa, T., Shigeoka, S. Arabidopsis NADPH oxidases, AtrbohD and AtrbohF, are essential for jasmonic acid-induced expression of genes regulated by MYC2 transcription factor. Plant Sci. 180, 655-60, 2011

37. Akashi, K., Yoshida, K., Kuwano, M., Kajikawa, M., Yoshimura, K., Hoshiyasu, S., Inagaki, N., Yokota, A. Dynamic changes in the leaf proteome of a C3 xerophyte, Citrullus lanatus (wild watermelon), in response to water deficit. Planta 233, 947-60, 2011

36. Ishikawa, K.*, Yoshimura, K.*, Ogawa, T., Shigeoka, S. Distinct regulation of Arabidopsis ADP-ribose/NADH pyrophosphohydrolases, AtNUDX6 and 7, in biotic and abiotic stress responses. Plant Signaling & Behavior 5, 695-697, 2010 *These authors contributed equally to this work.

35. Ishikawa, K.*, Yoshimura, K. *, Harada, K., Fukusaki, E., Ogawa, O., Tamoi, M., Shigeoka, S. AtNUDX6, an ADP-ribose/NADH pyrophosphohydrolase in Arabidopsis, positively regulates NPR1-dependent salicylic acid signaling. Plant Physiology 152, 2000-2012, 2010 *These authors contributed equally to this work.

34. Maruta, T., Tanouchi, A., Tamoi, M., Yabuta, Y., Yoshimura, K., Ishikawa, T., Shigeoka, S. Arabidopsis chloroplastic ascorbate peroxidase isoenzymes play a dual Role in photoprotection and gene regulation under photooxidative stress. Plant Cell Physiology 51, 190-200, 2010

33. Ishikawa, K., Ogawa, T., Hirosue, E., Nakayama, Y., Harada, K., Fukusaki, E., Yoshimura, K., Shigeoka, S. Modulation of the poly(ADP-ribosyl)ation reaction via the Arabidopsis ADP-ribose/NADH pyrophosphohydrolase, AtNUDX7, is involved in the response to oxidative stress. Plant Physiology 151, 741–754, 2009

32. Tanabe, N., Kimura, A., Yoshimura, K., Shigeoka, S. Plant-specific SR-related protein atSR45a interacts with spliceosomal proteins in plant nucleus. Plant Molecular Biology 70, 241–252, 2009

31. Ogawa, T., Ishikawa, K., Harada, K., Fukusaki, E., Yoshimura, K., Shigeoka, S. Overexpression of an ADP-ribose pyrophosphatase, AtNUDX2, confers enhanced tolerance to oxidative stress on Arabidopsis plants. Plant Journal 57, 289-301, 2009

30. Ogawa, T.*, Yoshimura, K.*, Miyake, H., Ishikawa, K., Ito, D., Tanabe, N., Shigeoka, S. Molecular characterization of organelle-type Nudix hydrolases in Arabidopsis thaliana. Plant Physiology 148, 1412-1424, 2008 *These authors contributed equally to this work.

29. Yabuta, Y., Maruta, T., Nakamura, A., Mieda, T., Yoshimura, K., Ishikawa, T., Shigeoka, S. Conversion of L-Galactono-1, 4-lactone to L-ascorbate is regulated by the photosynthetic electron transport chain in Arabidopsis. Bioscience, Biotechnology, and Biochemistry 72, 2598-2607, 2008

28. Akashi, K., Yoshimura, K., Nanasato, Y., Takahara, K., Munekage, Y., Yokota, A. Wild plant resources for studying molecular mechanisms of drought/high light stress tolerance. Plant Biotechnology 25, 257-263, 2008

27. Yoshimura, K., Masuda, A., Kuwano, M., Yokota, A., Akashi, K. Programmed proteome response for drought avoidance/tolerance in the root of a C3 xerophyte (wild watermelon) under water deficits. Plant Cell Physiology 49, 226-241, 2008

26. Yoshimura, K., Ogawa, T., Ueda, Y., Shigeoka, S. AtNUDX1, an 8-oxo-7, 8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase, is responsible for eliminating oxidized nucleotides in Arabidopsis. Plant Cell Physiology 48, 1438-1449, 2007

25. Yabuta, Y., Mieda, T., Parolu, M., Nakamura, A., Motoki, T., Maruta, T., Yoshimura, K., Ishikawa, T., Shigeoka, S. Light regulation of ascorbate biosynthesis is dependent on the photosynthetic electron transport chain but independent of sugars in Arabidopsis. Journal of Experimental Botany 58, 2661-2671, 2007

24. Tanabe, N., Yoshimura, K., Kimura, A., Yabuta, Y., Shigeoka, S. Differential expression of alternatively spliced mRNAs of Arabidopsis SR protein homologues, atSR30 and atSR45a, in response to environmental stress. Plant Cell Physiology 48, 1036-1049, 2007

23. Nishizawa, A., Yabuta, Y., Maruta, T., Yoshimura, K., Shigeoka, S. A transcription factor HsfA2 is the key regulator in the response to different types of stress in Arabidopsis. Plant Journal 48, 535-547, 2006

22. Gaber, A., Yoshimura, K., Yamamoto, T., Yabuta,Y., Takeda, T., Miyasaka, H., Nakano, Y., Shigeoka, S. Glutathione peroxidase-like protein of Synechocystis PCC 6803 confers tolerance to oxidative and environmental stresses in transgenic Arabidopsis via cell membrane protection. Physiologia Plantarum 128,251-262, 2006

21. Ogawa, T., Ueda, Y., Yoshimura, K., Shigeoka, S. Comprehensive analysis of cytosolic nudix hydrolases in Arabidopsis thaliana. Journal of Biological Chemistry 280, 25277-25283, 2005

20. Ohe, M., Papolu, M., Mieda, T., Miyagawa, Y., Yabuta, Y., Yoshimura, K., Shigeoka, S. Decline in leaf photooxidative-stress tolerance with age in tobacco. Plant Science 168, 1487-1493, 2005

19. Yabuta, Y., Maruta, T., Yoshimura, K., Ishikawa, T., Shigeoka, S. Two distinct redox signaling pathways for cytosolic APX induction under photooxidative stress. Plant Cell Physiology 45, 1586-1594, 2004

18. Mieda, T., Yabuta, Y., Madhusudhan, R., Motoki, T., Takeda, T., Yoshimura, K., Ishikawa, T., Shigeoka, S. Feedback inhibition of spinach L-galactose dehydrogenase by L-ascorbate. Plant Cell Physiology 45, 1271-1279, 2004

17. Gaber, A., Yoshimura, K., Tamoi, M., Takeda, T., Nakano, Y., Shigeoka, S. Induction and functional analysis of two NADPH-dependent glutathione peroxidase-like proteins in Synechocystis PCC 6803 during the progression of oxidative stress. Plant Physiology 136, 2855-2861, 2004

16. Yoshimura, K., Miyao, K., Gaber, A., Takeda, T., Kanaboshi, H., Miyasaka, H., Shigeoka, S. Enhancement of stress tolerance in transgenic tobacco plants overexpressing Chlamydomonas glutathione peroxidase in chloroplasts or cytosol. Plant Journal 37, 21-33, 2004

15. Wada, K., Tada, T., Nakamura, Y., Ishikawa, T., Yabuta, Y., Yoshimura, K., Shigeoka, S., Nishimura, K. Crystal structure of chloroplastic ascorbate peroxidase from tobacco plants and structural insights for its instability. Journal of Biochemistry 134, 239-244, 2003

14. Yabuta, Y., Motoki, T., Yoshimura, K., Takeda, T., Ishikawa, T., Shigeoka , S. Thylakoid-membrane bound ascorbate peroxidase is a limiting factor of antioxidative systems under photooxidative stress. Plant Journal 32, 915-925, 2002

13. Yoshimura, K., Yabuta, Y., Ishikawa, T., Shigeoka, S. Identification of a cis-element for tissue-specific alternative splicing of chloroplast ascorbate peroxidase pre-mRNA in higher plants. Journal of Biological Chemistry 277, 40623-40632, 2002

12. Shigeoka, S., Ishikawa, T., Tamoi, m., Miyagawa, Y., Takeda, T., Yabuta, Y., Yoshimura, K. Regulation and function of ascorbate peroxidase isozymes. Journal of Experimental Botany 53, 1305-1319, 2002

11. Wada, K., Tada, T., Nakamura, Y., Yoshimura, K., Takeda, T., Shigeoka, S., Nishimura, K. Crystallization and preliminary X-ray diffraction analysis of chloroplastic ascorbate peroxidase of tobacco plants. Acta Crystallographica Section D D58, 559-561, 2002

10. Yoshimura, K., Ishikawa, T., Wada, K., Takeda, T., Kamata, Y., Tada T., Nishimura, K., Nakano, Y., Shigeoka, S. Characterization of monoclonal antibodies against ascorbate peroxidase isoenzymes: Purification and epitope-mapping using immunoaffinity column chromatography. Biochimica et Biophysica Acta 1526, 168-174, 2001

9. Yabuta, Y., Yoshimura, K., Takeda, T., Shigeoka, S. Molecular characterization of tobacco mitochondrial L-galactono-g-lactone dehydrogenase and its expression in Escherichia coli. Plant Cell Physiology 41, 666-675, 2000

8. Yoshimura, K., Yabuta, Y., Ishikawa, T., Shigeoka, S. Expression of spinach ascorbate peroxidase isoenzymes in response to oxidative stresses. Plant Physiology 123, 223-234, 2000

7. Takeda, T., Yoshimura, K., Yoshii, M., Kanahoshi, H., Miyasaka, H., Shigeoka, S. Molecular characterization and physiological role of ascorbate peroxidase from halotolerant Chlamydomonas W80 strain. Archives of Biochemistry and Biophysics 376, 82-90, 2000

6. Yoshimura, K., Ishikawa, T., Tamoi, M., Shigeoka, S. Alternatively spliced mRNA variants of chloroplast ascorbate peroxidase isoenzymes in spinach leaves. Biochemical Journal 338, 41-48, 1999

5. Yoshimura, K., Ishikawa, T., Nakamura, Y., Tamoi, M., Takeda, T., Tada, T., Nishimura, K., Shigeoka, S. Comparative study on recombinant chloroplastic and cytosolic ascorbate peroxidase isozymes of spinach. Archives of Biochemistry and Biophysics 353, 55-63, 1998

4. Takeda, T., Yoshimura, K., Ishikawa, T., Shigeoka, S. Purification and characterization of ascorbate peroxidase in Chlorella vulgaris. Biochimie 80, 295-301, 1998

3. Ishikawa, T., Yoshimura, K., Sakai, K., Tamoi, M., Takeda, T., Shigeoka, S. Molecular characterization and physiological role of a glyoxysome-bound ascorbate peroxidase from spinach. Plant Cell Physiology 39, 23-34, 1998

2. Ishikawa, T., Yoshimura, K., Tamoi, M., Takeda, T., Shigeoka, S. Alternative mRNA splicing of 3'-terminal exons generates ascorbate peroxidase isoenzymes in spinach chloroplasts. Biochemical Journal 328, 795-800, 1997

1. Ishikawa, T., Sakai, K., Yoshimura, K., Takeda, T., Shigeoka, S. cDNAs encoding spinach stromal and thylakoid-bound ascorbate peroxidase, differing in the presence or absence of their 3'-coding regions. FEBS Letters 384, 289-293, 1996

Proceedings

5. Tanabe, T., Kimura, A., Yoshimura, K., Shigeoka, S. Identification of interacting factors with a high-light responsible SR protein, atSR45a, involved in the regulation of alternative splicing in Arabidopsis. 14th Photosynthesis Congress(22nd to 27th July 2007, at the SECC in Glasgow UK)Photosynthesis, Energy from the Sun, Springer Netherlands 1347-1350, 2008

4. Ogawa, T., Yoshimura, K., Shigeoka, S. Functional analysis of an 8-oxo-7,8-dihydro-2'-deoxyguanosine 5'-triphosphate pyrophosphohydrolase, AtNUDX1, involved in repair of oxidative DNA damage in Arabidopsis thaliana. 14th Photosynthesis Congress(22nd to 27th July 2007, at the SECC in Glasgow UK)Photosynthesis, Energy from the Sun, Springer Netherlands 1323-1326, 2008

3. Ogawa, T., Ueda, Y., Fujiwara, N., Yoshimura, K., Shigeoka, S. Identification of genes involved in tolerance to oxidative stress by activation tagging. 13th International Congress on Photosynthesis P1B-39, 2004

2. Yoshimura, K., Tanabe, N., Asano, M., Yokota, A., Shigeoka, S. Expression of Arabidopsis SR protein in response to various types of environmental stresses. 13th International Congress on Photosynthesis P1B-50, 2004

1. Yoshimura, K., Yabuta, Y., Ishikawa, T., Shigeoka, S. Regulation of tissue-specific alternative splicing of chloroplastic ascorbate peroxidase isoenzymes in spinach. 12th International Congress on Photosynthesis S20-009, 2001

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