CHUBU UNIVERSITY
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NISHIZAWA Yuji

Profile

Year of Birth 1963
Place of Birth Aichi
Title Professor
Belong to Dept. of Biomedical Sciences
Center for Clinical Examination Practicum Support
Biomedical Sciences (graduate school)
Graduated Nagoya University, Graduate School of Science
Degree Dr. of Science
Academic Institutional Membership The Japanese Association of Anatomists
Japan Society for Cell Biology
The Mass Spectrometry Society of Japan
Field of Study Anatomy, Cell Biology, Electron Microscopy, Biological Mass Spectrometory
Research, Studies Developmental biology of the photoreceptor cells during retinal degeneration.
Curriculum Specialized Anatomy, Histology, Cell Biology

Books Published, Translation

Tamiya-Koizumi K, Murate T, Tanaka K, Nishizawa Y, Morone N, Usukura J, Hirabayashi Y. (2006). Close Interrelationship of Sphingomyelinase and Caveolin in Triton X-100-insoluble Membrane Microdomains. Sphingolipid Biology, Springer-Verlag. Tokyo: 233-244.

Kitajima, Y., H.-M. Sheu, K. Owaribe, Y. Nishizawa and H. Yaoita (1992). Involvement of protein kinase C in the control of cell-cell and cell-matrix junctions in relation to differentiation of keratinocytes. The biology of the epidermis, Akira Ohkawara and Joseph McGuire, editors: 85-95.

Academic Papers, Critique

Ye F, Kaneko H, Hayashi Y, Takayama K, Hwang SJ, Nishizawa Y, Kimoto R, Nagasaka Y, Tsunekawa T, Matsuura T, Yasukawa T, Kondo T, Terasaki H. Malondialdehyde induces autophagy dysfunction and VEGF secretion in the retinal pigment epithelium in age-related macular degeneration. Free Radic Biol Med. 2016 Feb 23;94:121-134. doi: 10.1016/j.freeradbiomed.2016.02.027. [Epub ahead of print] PMID: 26923802

Mineo Kondo, Gautami Das, Ryoetsu Imai, Evelyn Santana, Tomio Nakashita, Miho Imawaka, Kosuke Ueda, Hirohiko Ohtsuka, Kazuhiko Sakai, Takehiro Aihara, Kumiko Kato, Masahiko Sugimoto, Shinji Ueno, Yuji Nishizawa, Gustavo D. Aguirre, Keiko Miyadera. A Naturally Occurring Canine Model of Autosomal Recessive Congenital Stationary Night Blindness. PloS One 2015 Sep 10(9): e0137072. doi:10.1371/journal.pone.0137072.

Hirako Y, Yonemoto Y, Yamauchi T, Nishizawa Y, Kawamoto Y, Owaribe K. Isolation of a hemidesmosome-rich fraction from a human squamous cell carcinoma cell line. Exp Cell Res. 2014 Jun 10;324(2):172-82. doi: 10.1016/j.yexcr.2014.04.002. Epub 2014 Apr 12.

Yamazaki A, Nishizawa Y, Matsuura I, Hayashi F, Usukura J, Bondarenko VA. Microtubule-associated protein tau in bovine retinal photoreceptor rod outer segments: comparison with brain tau. Biochim Biophys Acta. 2013 Oct;1832(10):1549-59. Epub 2013 May 24.

Liu HN, Ohya S, Nishizawa Y, Sawamura K, Iino S, Syed MM, Goto K, Imaizumi Y, Nakayama S. Serotonin Augments Gut Pacemaker Activity via 5-HT(3) Receptors. PLoS One. 2011;6(9):e24928. Epub 2011 Sep 15.

Kondo M, Sanuki R, Ueno S, Nishizawa Y, Hashimoto N, Ohguro H, Yamamoto S, Machida S, Terasaki H, Grazyna A, Furukawa T. Identification of Autoantibodies against TRPM1 in Patients with Paraneoplastic Retinopathy Associated with ON Bipolar Cell Dysfunction. PLoS ONE 2011 May6(5)[Epub]

Minobe S, Sakakibara A, Ohdachi T, Kanda R, Kimura M, Nakatani S, Tadokoro R, Ochiai W, Nishizawa Y, Mizoguchi A, Kawauchi T, Miyata T. Rac is involved in the interkinetic nuclear migration of cortical progenitor cells. Neuroscience Research. 2009 Apr;63(4):294-301.

Sugiura K, Muro Y, Futamura K, Matsumoto K, Hashimoto N, Nishizawa Y, Nagasaka T, Saito H, Tomita Y, Usukura J. The Unfolded Protein Response Is Activated in Differentiating Epidermal Keratinocytes. Journal of Investigative Dermatology 2009 Mar;12 [Epub ahead of print]

Kondo M, Sakai T, Komeima K, Kurimoto Y, Ueno S, Nishizawa Y, Usukura J, Fujikado T, Tano Y, Terasaki H. Generation of a Transgenic Rabbit Model of Retinal Degeneration. Investigative Ophthalmology and Visual Sciences 2009 Mar(50):1371-7 [Epub 2008 Dec 13]

Koyasu, T., Kondo, M., Miyata, K., Ueno, S., Miyata, T., Nishizawa, Y. and Terasaki, H. Photopic Electroreinograms of mGluR6-Deficient Mice. Current Eye Research. 2008(33): 91-99.

Nishizawa, Y., Imafuku, H., Saito, K., Kanda, R., Kimura, M., Minobe, S., Masaoka, M., Ogawa, M. and Miyata, T. Survey of the morphogenetic dynamics of the ventricular surface of the developing mouse neocortex. Developmental Dynamics. 2007(236): 3061-3070.

Tamai, H., Shinohara, H., Miyata, T., Saito, K., Nishizawa, Y., Nomura, T. and Osumi, N.: Pax6 transcription factor regulates interkinetic nuclear movement in cortical progenitor cells via centrosomal stabilization. Genes to Cells. 2007(12): 983-996.

Sugiura K, Muro Y, Nishizawa Y, Okamoto M, Shinohara T, Tomita Y, Usukura J. LEDGF/DFS70, a Major Autoantigen of Atopic Dermatitis, Is a Component of Keratohyalin Granules. J Investigative Dermatology. 2007 Jan;127(1):75-80. Epub 2006 Jul 20.

Ueno S, Kondo M, Miyata K, Hirai T, Miyata T, Usukura J, Nishizawa Y, Miyake Y. Physiological function of S-cone system is not enhanced in rd7 mice. Exp Eye Res. 2005(81):751-758.

Nakayama S, Ohya S, Liu HN, Watanabe T, Furuzono S, Wang J, Nishizawa Y, Aoyama M, Murase N, Matsubara T, Ito Y, Imaizumi Y, Kajioka S. Sulphonylurea receptors differently modulate ICC pacemaker Ca2+ activity and smooth muscle contractility. J Cell Sci. 2005(118):4163-73.

Uematsu J, Nishizawa Y, Hirako Y, Kitamura K, Usukura J, Miyata T, Owaribe K. Both type-I hemidesmosomes and adherens-type junctions contribute to the cell-substratum adhesion system in myoepithelial cells. Eur J Cell Biol. 2005 Mar;84(2-3):407-15.

Makino A, Ozaki Y, Matsubara H, Sato T, Ikuta K, Nishizawa Y, Suzumori K. Role of apoptosis controlled by cytochrome c released from mitochondria for luteal function in human granulosa cells. Am J Reprod Immunol. 2005 Mar;53(3):144-52.

Uemura A, Nakamura M, Kachi S, Nishizawa Y, Asami T, Miyake Y, Terasaki H. Effect of plasmin on laminin and fibronectin during plasmin-assisted vitrectomy. Arch Ophthalmol. 2005 Feb;123(2):209-13.

Miyata T, Saito K, Nishizawa Y, Murayama A, Masaoka M and Ogawa M. Modern slice culture for direct observation of production and migration of brain neurons. Nagoya Journal of Medical Science. 2005, 67:65-70

Kaminski M, Niemczyk E, Masaoka M, Karbowski M, Hallmann A, Kedzior J, Majczak A, Knap D, Nishizawa Y, Usukura J, Wozniak M, Klimek J, Wakabayashi T. The switch mechanism of the cell death mode from apoptosis to necrosis in menadione-treated human osteosarcoma cell line 143B cells. Microsc Res Tech. 2004 64: 255-268.

Kaminski M, Masaoka M, Karbowski M, Kedzior J, Nishizawa Y, Usukura J, Wakabayashi T. Ultrastructural basis for the transition of cell death mode from apoptosis to necrosis in menadione-treated osteosarcoma 143B cells. J Electron Microsc (Tokyo). 2003 52: 313-325.

Hirako, Y., Y. Nishizawa, C. Sitaru, A. Opitz, K. Marcus, H. Meyer, E. Butt, K. Owaribe and D. Zillikens. The 97-kDa (LABD97) and 120-kDa (LAD-1) fragments of bullous pemphigoid antigen 180/type XVII collagen have different N-termini. Journal of Investigative Dermatology. 2003 121: 1554-1556.

Hirako, Y., H. Yamakawa, Y. Tsujimura, Y. Nishizawa, M. Okumura, J. Usukura, H. Matsumoto, K. Jackson, K. Owaribe and O. Ohara. Characterization of mammalian synemin, an intermediate filament protein present in all four classes of muscle cells and some neuroglial cells: co-localization and interaction with type III intermediate filiament proteins and keratins. Cell Tissue Res 2003 313: 195-207.

Spodonik, J., M. Wozniak, D. Budzko, M. Teranishi, M. Karbowski, Y. Nishizawa, J. Usukura and T. Wakabayashi. Mechanism of leflunomide-induced proliferation of mitochondria in mammalian cells. Mitochondrion 2002 2: 163-179.

Murata, T., F. Goshima, Y. Nishizawa, T. Daikoku, H. Takakuwa, K. Ohtsuka, T. Yoshikawa and Y. Nishiyama. Phosphorylation of cytokeratin 17 by herpes simplex virus type 2 US3 protein kinase. Microbiology and Immunology 2002 46: 707-719.

Nishizawa, Y., J. Usukura, D. P. Singh, L. T. J. Chylack and T. Shinohara. Spatial and temporal dynamics of two alternatively spliced regulatory factors, lens epithelium-derived growth factor (ledgf/p75) and p52, in the nucleus. Cell Tissue Res 2001 305: 107-114.

Karbowski, M., J. Spodonik, M. Teranishi, M. Wozniak, Y. Nishizawa, J. Usukura and T. Wakabayashi. Opposite effects of microtubule-stabilizing and microtubule-destabilizing drugs on biogenesis of mitochondria in mammalian cells. Journal of Cell Science 2001 114: 281-291.

Wakabayashi, T., M. Teranishi, M. Karbowski, Y. Nishizawa, J. Usukura, C. Kurono and T. Soji (2000). Functional aspects of megamitochondria isolated from hydrazine- and ethanol- treated rat livers. Pathology International 50: 20-33.

Usukura, J., Y. Nishizawa, A. Shimomura, K. Kobayashi, T. Nagatsu and M. Hagiwara (2000). Direct imaging of phosphorylation-dependent conformational change and DNA binding of CREB by electron microscopy. Gene to Cell 5: 515-522.

Nishizawa, Y. and H. Mastumoto (1999). Rapid making a photoreceptor protein catalogue using mass spectrometry. Journal of the Mass Spectrometry Society of Japan 47(3): 177-182.

Teranishi, M., M. Karbowski, C. Kurono, Y. Nishizawa, J. Usukura, T. Soji and T. Wakabayashi (1999). Effects of coenzyme Q10 on changes in the membrane potential and rate of generation of reactive oxygen species in hydrazine- and chloramphenicol-treated rat liver mitochondria. Archives of Biochemistry and Biophysics 366(1): 157-167.

Okumura, M., J. Uematsu, Y. Hirako, Y. Nishizawa, H. Shimizu, N. Kido and K. Owaribe (1999). Identification of the Hemidesmosomal 500 kDa Protein (HD1) as Plectin. Journal of Biochemistry 126: 1144-1150.

Nishizawa, Y., N. Komori, J. Usukura, K. Jackson, S. Tobin and H. Matsumoto (1999). Initiating ocular proteomics for cataloging retinal proteins: Microanalytical techniques permit the identification of proteins derived from a novel photoreceptor preparation. Experimental Eye Research 69: 195-212.

Karbowski, M., C. Kurono, M. Wozniak, M. Ostrowski, M. Teranishi, Y. Nishizawa, J. Usukura, T. Soji and T. Wakabayashi (1999). Free radical-induced megamitochondria formation and apoptosis. Free Radical Biology and Medicine 26: 396-409.

Kachi, S., Y. Nishizawa, E. Olshevskaya, A. Yamazaki, Y. Miyake, T. Wakabayashi, A. Dizhoor and J. Usukura (1999). Detailed localization of photoreceptor guanylate cyclase activating protein-1 and -2 in mammalian retinas using light and electron microscopy. Experimental Eye Research 68: 465-473.

Seno, K., A. Kishigami, S. Ihara, T. Maeda, A. V. Bondarenko, Y. Nishizawa, J. Usukura, A. Yamazaki and F. Hayashi (1998). A possible role of RGS9 in phototransduction. Journal of Biological Chemistry 273(35): 22169-22172.

Nagai, Y., T. Kojima, Y. Muro, T. Hachiya, Y. Nishizawa, T. Wakabayashi and M. Hagiwara (1997). Identification of a novel nuclear speckle-type protein, SPOP. FEBS Letters 418: 23-26.

Karbowski, M., C. Kurono, Y. Nishizawa, Y. Horie, T. Soji and T. Wakabayashi (1997). Induction of megamitochondria by some chemicals inducing oxidative stress in primary cultured rat hepatocyes. Biochimica et Biophysica ACTA/General Subjects 1349: 242-250.

Matsuhashi, T., X. Liu, Y. Nishizawa, J. Usukura, M. Wozniak and T. Wakabayashi (1996). Mechanism of the formation of megamitochondria in the mouse liver induced by chloramphenicol. Toxicology Letters 86: 47-54.

Hirako, Y., J. Usukura, Y. Nishizawa and K. Owaribe (1996). Demonstration of the molecular shape of BP180, a 180-kDa bullous pemphigoid antigen and its potential for trimer formation. Journal of Biological Chemistry 271: 13739-13745.

Arai, M., Y. Nishizawa, X. Liu, J. Usukura, S. Awaya and T. Wakabayashi (1995). Confocal imaging of megamitochondria formation induced by ethanol and hydrazine in culture cells (RL-34). Bioimages 3: 25-30.

Adachi, K., T. Matsuhashi, Y. Nishizawa, J. Usukura, J. Popinigis and T. Wakabayashi (1995). Suppression of the hydrazine-induced formation of megamitochondria in the rat liver by CoQ10. Toxicologic Pathology 23: 667-676.

Adachi, K., T. Matsuhashi, Y. Nishizawa, J. Usukura, J. Popinigis and T. Wakabayashi (1995). Studies on urea synthesis in the rat liver of rats treated chronically with ethanol using perfused livers, isolated hepatocytes and mitochondria. Biochemical Pharmacology 50: 1391-1399.

Uematsu, J., Y. Nishizawa, A. Sonnenberg and K. Owaribe (1994). Demonstration of type II hemidesmosomes in a mammary gland epithelial cell line, BMGE-H. Journal of Biochemistry 115: 469-476.

Liu, X., K. Seno, Y. Nishizawa, F. Hayashi, A. Yamazaki, H. Matsumoto, T. Wakabayashi and J. Usukura (1994). Ultrastructural localization of retinal guanylate cyclase in human and monkey retina. Experimental Eye Research 59: 761-768.

Antosiewicz, J., Y. Nishizawa, X. Liu, J. Usukura and T. Wakabayashi (1994). Suppression of the hydrazine-induced formation of megamitochondria in the rat liver by alpha-tocopherol. Experimental Molecular Pathology 60: 173-187.

Adachi, K., Y. Nishizawa, J. Usukura, M. Momota, J. Popinigis and T. Wakabayashi (1994). Further studies on physicochemical properties of mitochondrial membranes during the formation process of megamitochondria in the rat liver by hydrazine. Experimental Molecular Pathology 61: 134-151.

Usukura, J., Y. Nishizawa and T. Wakabayashi (1993). Three-demensional imaging of the cytoskeletal organization of actin filaments in rod photoreceptor cells. Bioimages 1(2): 181-187.

Nishizawa, Y., J. Uematsu and K. Owaribe (1993). HD4, a 180 kDa bullous pemphigoid antigen, is a major transmembrane glycoprotein of the hemidesumosome. J. Biochem. 113: 493-501.

Kitajima, Y., K. Owaribe, Y. Nishizawa, Y. Jokura and H. Yaoita (1992). Phorbol ester- and calcium-induced reorganization of 180-kDa bullous pemphigoid antigen on the ventral surface of cultured human keratinocytes as studied by immunofluorescence and immunoelectron microscopy. Exerimental Cell Research 203(1): 17-24.

Kitajima, Y., K. Owaribe, Y. Nishizawa and H. Yaoita (1992). Control of the distribution of hemidesmosome components in cultured keratinocytes: Ca2+ and phorbol esters. Journal of Dermatology 19(11): 770-773.

Hieda, Y., Y. Nishizawa, J. Uematsu and K. Owaribe (1992). Identification of a new hemidesmosomal protein, HD1: a major, high molecular mass component of isolated hemidesmosomes. Journal of Cell Biology 116(6): 1497-1506.

Owaribe, K., Y. Nishizawa and W. Franke (1991). Isolation and characterization of hemidesmosomes from bovine corneal epithelial cells. Experimental Cell Research 192(2): 622-630.

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