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WOO Je-Tae


Year of Birth 1961
Place of Birth Korea
Title Professor
Belong to Dept. of Biological Chemistry
Bioscience and Biotechnology (graduate school)
Research Institute for Biological Functions
Graduated Tokyo University of Agriculture and Technology, Graduate School of Agriculture
Degree Dr. of Agriculture, Tokyo University of Agriculture and Technology
Dr. of Mediclicine, Tokyo Medical University
Academic Institutional Membership Japan Society for Bioscience, Biotechnology, and Agrochemistry, Japanese Association for Animal Cell Technology, American Society for Bone and Mineral Research
Field of Study Bioactive Natural Products and Cellular Biochemistry
Research, Studies Screening, Isolation and Biological Activities of Natural Products
Curriculum Specialized Chemistry of Natural Products, Cellular Biochemistry of Bioactive Compounds, Cell Technology

Books Published, Translation

Dietary flavonoids and their effects on osteoclast differentiation and function. Bromacology: Pharmacology of Foods and Their Components Research Signpost, 35-52., 2008

Cahallenges of nutriproteimics for Bromacology Bromacology: Pharmacology of Foods and Their Components Research Signpost., 171-188., 2008

Academic Papers, Critique

Nobiletin improves hyperglycemia and insulin resistance in obese diabetic ob/ob mice. Biochem Pharmacol. in press, 2010

Phytochemicals that stimulate osteoblastic differentiation and bone formation. J Oral Biosci. 52, 2010

Honokiol inhibits osteoclast differentiation and function in vitro. Biol Pharm Bull. 33, 2010

Inhibitory effect of luteolin on osteoclast differentiation and function. Cytotechnology. 61, 2009

Magnolol enhances adipocyte differentiation and glucose uptake in 3T3-L1 cells. Life Sci. 84, 2009

An inhibitory effect of chrysoeriol on platelet-derived growth factor (PDGF)-induced proliferation and PDGF receptor signaling in human aortic smooth muscle cells. J Pharmacol Sci. 110, 2009

Antiresorptive microbial compounds that inhibit osteoclast differentiation, function and survival. J Pharmacol Sci. 106, 2008

Tributyltin and triphenyltin inhibit osteoclast differentiation through a retinoic acid receptor-dependent signaling pathway. Biochem Biophys Res Commun. 355, 2007

Identification of two biologically crucial hydroxyl groups of (-)-epigallocatechin gallate in osteoclast culture. Biochem Pharmacol. 73, 2007

Reveromycin A, an agent for osteoporosis, inhibits bone resorption by inducing apoptosis specifically in osteoclasts. Proc Natl Acad Sci U S A. 103, 2006

Curcumin inhibits the proliferation and mineralization of cultured osteoblasts. Eur J Pharmacol. 534, 2006

Inhibitory effects of mevastatin and a geranylgeranyl transferase I inhibitor on mononuclear osteoclast formation induced by RANKL or TNF-alpha. Biochem Pharmacol. 69, 2005

Cyclosporine A and FK506 induce osteoclast apoptosis in mouse bone marrow cell cultures. Bone, Vol.35, 2004

Quercetin suppresses bone resorption by inhibiting the differentiation and activaon of osteoclasts. Biol. Pharm. Bull., Vol.27, 2004

Destruxins, cyclodepsipeptides, block the formation of actin rings and prominent clear zones and ruffled borders in osteoclasts. Bone, Vol.33, 2003

Insulin-dependent adipogenesis in stromal ST2 cells derived from murine bone marrow. Biosci. Biotechnol. Biochem. Vol.67, 2003

Fenton reaction is primarily involved in a mechanism of(-)-epigallocatechin-3-gallate to induce osteoclastic cell death, Biochem. Biophys. Res. Commun. Vol.292, 2002

Compactin suppresses bone resorption by inhibiting the fusion of prefusion osteoclasts and disrupting the actin ring in osteoclasts. J. Bone Miner. Res., Vol.15, 2000

RANKL and IL-1 induce the fusion of mononuclear preosteoclasts into multinucleated osteoclasts through their receptors by activating NFκ-B. Cytotechnology, Vol.33, 2000

0steoblastic cells induce fusion and activation of osteoclasts through a mechanism independent of macrophage-colony stimulating factor production. Cell Tissue Res, Vol.298, 1999

Requirement of osteoblasts for the fusion of preosteoclasts. J. Bone Miner. Met. Vol.16, 1998

Ca2+-ATPase inhibitors and Ca2+-ionophores induce osteoclast formation in the coculture of mouse bone marrow cells and osteoblastic cells. Biochem. Biophy. Res. Comm. Vol.237, 1997

Prodigiosin 25-C and metacycloprodigiosin suppresses bone resorption by osteoclasts. Biosci. Biotech. Biochem., Vol.59, 1997


Bone Resorption Inhibitor, Japan Patent 11-246406, 1998

Bone Resorption Inhibitor, Japan Patent 11-246405, 1998

Cysteine Protease Inhibitors, Bone Resorption Inhibitors and Peptide Derivatives, Japan Patent 08-092193, 1996

Polygalacturonase Inhibitors, Japan Patent 08-081489, 1996

Bioactive Peptide Compounds, Japan Patent 07-070098, 1995

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