CHUBU UNIVERSITY
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TSURUDOME Masato

Profile

Year of Birth 1955
Place of Birth Kagoshima Prefecture
Title Professor
Belong to Dept. of Biomedical Sciences
Center for Clinical Examination Practicum Support
Biomedical Sciences (graduate school)
Graduated The University of Tokyo
Degree Doctor of Agriculture (The University of Tokyo), Doctor of Medicine (Mie University)
Qualification Veterinarian
Academic Institutional Membership The Japanese Society for Virology
The Japanese Society of Veterinary Science
American Society for Microbiology
Field of Study Virology, Molecular Biology
Research, Studies Molecular Mechanism of Viral Membrane Fusion

Books Published, Translation

Negative Strand RNA Virus, World Scientific Publishing Co. Pte. Ltd., 2011.

Viral Fusion Mechanisms, CRC Press, 1993.

Academic Papers, Critique

31. Ohtsuka J, Matsumoto Y, Ohta K, Fukumura M, Tsurudome M, Nosaka T, and Nishio M. Nucleocytoplasmic shuttling of the human parainfluenza virus type 2 phosphoprotein. Virology 528:54-63. 2018.

30. Tsurudome M, Ohtsuka J, Ito M, Nishio M, and Nosaka T: The hemagglutinin-neuraminidase (HN) head domain and the fusion (F) protein stalk domain of the parainfluenza viruses affect the specificity of the HN-F interaction. Front Microbiol. 9:Article 391, 2018.

29. Goto H, Ihira H, Morishita K, Tsuchiya M, Ohta K, Yumine N, Tsurudome M, and Nishio M: Enhanced growth of influenza A virus by coinfection with human parainfluenza virus type 2. Med. Microbiol. Immunol. 205:209-218, 2016.

28. Ohta K, Goto H, Matsumoto Y, Yumine N, Tsurudome M, and Nishio M: Graf1 controls the growth of human parainfluenza virus type 2 through inactivation of RhoA signaling. J. Virol. 90:9394-9405, 2016.

27. Ito M, Kubota H, Takeuchi T, Qiao S, Tsurudome M:, Tsumura H, Matsuda A, Nishio M, and Ito Y. Pathogenesis of the influenza virus in diabetes model mice. Brit. Microbiol,. Res J. 9:1-7 2015.

26. Tsurudome M, Ito M, Ohtsuka J, Hara K, Komada H, Nishio M, and Nosaka T: The fusion protein specificity of the parainfluenza virus hemagglutinin- neuraminidase protein is not solely defined by the primary structure of its stalk domain. J. Virol. 89:12374-12387, 2015.

25. Ohtsuka J, Fukumura M, Tsurudome M, Hara K, Nishio M, Kawano M, and Nosaka T: Vero/BC-F: an efficient packaging cell line stably expressing F protein to generate single round-infectious human parainfluenza virus type 2 vector. Gene Ther. 21:775-784, 2014.

24. Tsurudome M, Nakahashi M, Matsushima Y, Ito M, Nishio M, Kawano M, Komada H, and Nosaka T: Full conversion of the hemagglutinin- neuraminidase specificity of the parainfluenza virus 5 fusion protein by replacement of 21 amino acids in its head region with those of the simian virus 41 fusion protein. J. Virol. 87:8342-8350, 2013.

23. Tsurudome M, Ito M, Nishio M, Nakahashi M, Kawano M, Komada H, Nosaka T, and Ito Y: Identification of domains on the fusion (F) protein trimer that influence the hemagglutinin-neuraminidase specificity of the f protein in mediating cell-cell fusion. Virol. 85:3153-3161, 2011.

22. Nishio M, Tsurudome M, Garcin D, Komada H, Ito M, Le Mercier P, Nosaka T, and Kolakofsky D: Human parainfluenza virus type 2 L protein regions required for interaction with other viral proteins and mRNA capping. J. Virol. 85:725-732, 2011.

21. Ito M, Yamakawa I, Nishio M, Tsurudome M, Kawano M, Komada H, and Ito Y: A quantitative method for analyzing establishing-efficiency of persistent viral infection. Microbiol. Immunol. 53:259-265, 2009.

20. Tsurudome M, Nishio M, Ito M, Tanahashi S, Kawano M, Komada H, and Ito Y: Effects of hemagglutinin-neuraminidase protein mutations on cell-cell fusion mediated by human parainfluenza type 2 virus. J. Virol. 82:8283-8295, 2008.

19. Nishio M, Ohtsuka J, Tsurudome M, Nosaka T, and Kolakofsky D: Human parainfluenza virus type 2 V protein inhibits genome replication by binding to the L protein: possible role in promoting viral fitness. J. Virol. 82:6130-6138, 2008.

18. Ito M, Nishio M, Kawano M, Komada M, Ito Y, and Tsurudome M: Effects of multiple amino acids of the parainfluenza virus 5 fusion protein on the haemagglutinin- neuraminidase-independent fusion activity. J. Gen. Virol. 90:405-413, 2009.

17. Ohkubo T, Nishio M, Tsurudome M, Ito M, and Ito Y: Existence of leptin receptor protein in chicken tissues: isolation of a monoclonal antibody against chicken leptin receptor. Gen. Comp. Endocrinol. 151:269-273, 2007.

16. Tsurudome M, Ito M, Nishio M, Kawano M, Komada H, and Ito Y: A mutant fusion (F) protein of simian virus 5 induces hemagglutinin-neuraminidase- independent syncytium formation despite the internalization of the F protein. Virology 347:11-27, 2006.

15. Ito M, Takeuchi T, Nishio M, Kawano M, Komada H, Tsurudome M, and Ito Y: Early stage of establishment of persistent Sendai virus infection: unstable dynamic phase and then selection of viruses which are tightly cell associated, temperature sensitive, and capable of establishing persistent infection. J. Virol. 78:11939-11951, 2004.

14. Okamoto Y, Sakata M, Ogura K, Yamamoto T, Yamaguchi M, Tasaka K, Kurachi H, Tsurudome M, and Murata Y: Expression and regulation of 4F2hc and hLAT1 in human trophoblasts. Am. J. Physiol Cell Physiol. 282:C196-C204, 2002.

13. Ito M, Takebayashi S-I, Okumura K, Ohkubo T, Nishio M, Kawano M, Komada H, Ito Y, and Tsurudome M: Up-regulated expression of a novel gene in activated human peripheral blood mononuclear cells that is a truncated paralog of the human system L-amino acid transporter 1. Int. J. Biochem. Cell Biol. 34:1152-1163, 2002.

12. Tsurudome M, Ito M, Nishio M, Kawano M, Komada H, and Ito Y: Hemagglutinin-neuraminidase-independent fusion activity of simian virus 5 fusion (F) protein: difference in conformation between fusogenic and nonfusogenic F proteins on the cell surface. J. Virol. 75:8999-9009, 2001.

11. Ito M, Nishio M, Komada H, Ito Y, and Tsurudome M: An amino acid in the heptad repeat 1 domain is important for the haemagglutinin-neuraminidase- independent fusing activity of simian virus 5 fusion protein. J. Gen. Virol. 81:719-727, 2000.

10. Tsurudome M, Ito M, Takebayashi S-I, Okumura K, Nishio M, Kawano M, Kusagawa S, Komada H, and Ito Y: Cutting edge: Primary structure of the light chain of fusion regulatory protein-1/CD98/4F2 predicts a protein with multiple transmembrane domains that is almost identical to the amino acid transporter E16. J. Immunol. 162:2462-2466, 1999.

9. Tsurudome M, Ito M, Nishio M, Kawano M, Okamoto K, Kusagawa S, Komada H, and Ito Y: Identification of regions on the fusion protein of human parainfluenza virus type 2 which are required for haemagglutinin-neuraminidase proteins to promote cell fusion. J. Gen. Virol. 79:279-289, 1998.

8. Ito M, Nishio M, Kawano M, Kusagawa S, Komada H, Ito Y, and Tsurudome M: Role of a single amino acid at the amino terminus of the simian virus 5 F2 subunit in syncytium formation. J. Virol. 71:9855-9858, 1997.

7. Tsurudome M, Kawano M, Yuasa T, Tabata N, Nishio M, Komada H, and Ito Y: Identification of regions on the hemagglutinin-neuraminidase protein of human parainfluenza virus type 2 important for promoting cell fusion. Virology 213:190-203, 1995.

6. Yuasa T, Kawano M, Tabata N, Nishio M, Kusagawa S, Komada H, Matsumura H, Ito Y, and Tsurudome M: A cell fusion-inhibiting monoclonal antibody binds to the presumed stalk domain of the human parainfluenza type 2 virus hemagglutinin-neuraminidase protein. Virology 206:1117-1125, 1995.

5. Tsurudome M, Gl├╝ck R, Graf R, Falchetto R, Schaller U, and Brunner J: Lipid interactions of the hemagglutinin HA2 NH2-terminal segment during influenza virus-induced membrane fusion. J. Biol. Chem. 267:20225-20232, 1992.

4. Tsurudome M, Bando H, Kawano M, Matsumura H, Komada H, Nishio M, and Ito Y: Transcripts of simian virus 41 (SV41) matrix gene are exclusively dicistronic with the fusion gene which is also transcribed as a monocistron. Virology 184:93-100, 1991.

3. Tsurudome M, Bando H, Nishio M, Iwamoto Y, Kawano M, Kondo K, Komada H, and Ito Y: Antigenic and structural properties of a paramyxovirus simian virus 41 (SV41) reveal a close relationship with human parainfluenza type 2 virus. Virology 179:738-748, 1990.

2. Tsurudome M, Nishio M, Komada H, Bando H, and Ito Y: Extensive antigenic diversity among human parainfluenza type 2 virus isolates and immunological relationships among paramyxoviruses revealed by monoclonal antibodies. Virology 171:38-48, 1989.

1. Tsurudome M, Yamada A, Hishiyama M, and Ito Y: Monoclonal antibodies against the glycoproteins of mumps virus: fusion inhibition by anti-HN monoclonal antibody. J. Gen. Virol. 67:2259-2265, 1986.

Lectures, Symposium, Presentation

7. Tsurudome M, Ito M, Nishio M. The hemagglutinin-neuraminidase (HN) head domain and the fusion (F) protein stalk domain of the parainfluenza viruses affect the specificity of the HN-F interaction. XVII International Conference on Negative Strand Viruses,Verona (Italy), 2018.

6. Tsurudome M, Ito M, Nishio M, Nosaka T. The F specificity of the parainfluenza virus HN is not defined solely by the primary structure of the HN stalk domain. XVI International Conference on Negative Strand Viruses, Siena (Italy), 2015.

5. Tsurudome M, Ito M, Nishio M, and Nosaka T. Conversion of the parainfluenza virus 5 F protein to a simian virus 41 HN-specific protein by amino acid substitutions. XV International Conference on Negative Strand Viruses, Granada(Spain), 2013.

4. Tsurudome M, Ito M, Nishio M, and Ito Y: Identification of domains on the trimer surface of the fusion (F) protein that influence the hemagglutinin-neuraminidase specificity of the F protein in mediating cell-cell fusion. XIV International Conference on Negative Strand Viruses, Brugge (Belgium), 2010.

3. Tsurudome M, Nishio M, Ohtsuka J, and Kawano M: Mapping of the domains on the paramyxovirus fusion protein that determine hemagglutinin-neuraminidase specificity in mediating syncytium formation. Workshop on Replication and Cell Biology of Negative Strand RNA Viruses, Evanston (USA), 2007.

2. Bateman A, Chinnery F, Tsurudome M, King C, Khakoo S, and Elliott T: Paramyxovirus HN expression promotes tumor immunity via NK activation. Keystone Symposia: Basic Aspects of Tumor Immunology, Keystone (USA), 2005.

1. Tsurudome M, Ito M, Nishio M, and Ito Y: Hemagglutinin-neuraminidase-independent fusing activity of simian virus 5 fusion protein: involvement of a conformational change in the head domain. XII International Conference on Negative Strand Viruses, Pisa (Italy), 2003.

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