CHUBU UNIVERSITY
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NAKAGAWA Hiroshi

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Title Associate Professor
Belong to Dept. of Biological Chemistry
Bioscience and Biotechnology (graduate school)
Graduated Graduate School of Bioscience and Biotechnology, Tokyo Institute of Technology
Degree Ph.D.
Field of Study Animal Cell Technology, Physiological Genetics
Research, Studies

Academic Papers, Critique

Tsukamoto, M., Yamashita, M., Nishi, T., and Nakagawa, H., A human ABC transporter ABCC4 gene SNP (rs11568658, 559 G>T, G187W) reduces ABCC4-dependent drug resistance. Cells, 8, E39., (2019)

Mitani, Y., Satake, K., Tsukamoto, M., Nakamura, I., Kadioglu, O., Teruya, T., Yonezawa, T., Cha, BY., Efferth, T., Woo, JT., and Nakagawa, H., Epimagnolin A, a tetrahydrofurofuranoid lignan from Magnolia fargesii, reverses ABCB1-mediated drug resistance. Phytomedicine, 51, 112-119., (2018)

Nakagawa, H., Toyoda, Y., Albrecht, T., Tsukamoto, M., Praetorius, M. Ishikawa, T., Kamiya, K., Kusunoki, T., Ikeda, K., and Sertel, S., Are human ATP-binding cassette transporter C11 and earwax associated with the incidence of cholesteatoma? Med. Hypotheses. 114, 19-22., (2018)

Tsukamoto, M., Sato, S., Satake, K., Miyake, M., and Nakagawa, H., Quantitative evaluation of drug resistance profile of cells expressing wild-type or genetic polymorphic variants of the human ABC transporter ABCC4. Int. Journal of Molecular Sciences. 18, E1435., (2017)

Satake, K., Tsukamoto, M., Mitani, Y., Regasini, LO., Bolzani Vda, S., Efferth, T., and Nakagawa, H., Human ABCB1 confers cells resistance to cytotoxic guanidine alkaloids from Pterogyne nitens.. Biomed. Mater. Eng., 25, 249-256., (2015)

Tajima, Y., Nakagawa, H., Tamura, A., Kadioglu, O., Satake, K., Mitani, Y., Murase, H., Regasini LO, Bolzani Vda S, Ishikawa, T., Fricker, G., and Efferth, T., Nitensidine A, a guanidine alkaloid from Pterogyne nitens, is a novel substrate for human ABC transporter ABCB1. Phytomedicine, 21, 323-332. Tajima, Y. and Nakagawa, H. contributed equally to this work., (2014)

Nakagawa, H., Toyoda, Y., Wakabayashi-Nakao, K., Tamaki, H., Osumi, M., and Ishikawa, T., Ubiquitin-mediated proteasomal degradation of ABC transporters: A new aspect of genetic polymorphisms and clinical impacts. J. Pharm. Sci., 100, 3602-3619., (2011)

Nakagawa, H., Wakabayashi-Nakao, K., Tamura, A., Koshiba, S., Toyoda, Y., and Ishikawa, T., Disruption of N-linked glycosylation enhances ubiquitin-mediated proteasomal degradation of human ATP-binding cassette transporter ABCG2. FEBS J., 276, 7237-7252., (2009)

Nakagawa, H., Tamura, A., Wakabayashi, K., Hoshijima, K., Komada, M., Yoshida, T., Kometani, S., Matsubara, T., Mikuriya, K., and Ishikawa, T., Evidence for ubiquitin-mediated proteasomal degradation of non-synonymous SNP Variants. Biochemical J., 411, 623-631., (2008)

Nakagawa, H., Hasumi, K., Takami, M., Aida-Hyugaji, S., Woo, JT., Nagai, K., Ishikawa, T., and Wachi, M., Identification of two biologically-crucial hydroxyl groups of (–)-epigallocatechin gallate in osteoclast culture. Biochem. Pharmacol., 73, 34-43., (2007)

Nakagawa, H., Hasumi, K., Woo, JT., Nagai, K., and Wachi, M., Generation of hydrogen peroxide primarily contributes to the induction of Fe(II)-dependent apoptosis in Jurkat cells by (–)-epigallocatechin gallate. Carcinogenesis, 25, 1567-1574., (2004)

Nakagawa, H., Takami, M., Udagawa, N., Sawae, Y., Suda, K., Sasaki, T., Takahashi, N., Wachi, M., Nagai, K., and Woo, JT., Destruxins, cyclodepsipeptides, block the formation of actin rings, and prominent clear zones and ruffled borders in osteoclasts. Bone, 33, 443-455., (2003)

Nakagawa, H., Wachi, M., Woo, JT., Kato, M., Kasai, S., Takahashi, F., Lee, IS., and Nagai, K., Fenton reaction is primarily involved in a mechanism of (-)-epigallocatechin-3-gallate to induce osteoclastic cell death. Biochem. Biophys. Res. Commun., 292, 94-101., (2002)

Lectures, Symposium, Presentation

Nakagawa, H., Tamura, A., Li, S., Aida-Hyugaji, S., Regasini LO, Bolzani Vda S, Hirose, S., Ishikawa, T., Fricker, G., and Efferth, T., The combination of isoprenyl and guanidium core structural units influences the affinity level of guanidine alkaloid for human ATP-Binding Cassette Transporter ABCB1. The FEBS-ABC2012 – 4th FEBS Special Meeting on ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases., (March, 2012. Innsbruck)

Nakagawa, H., Wakabayashi-Nakao, K., Tamura, A., Koshiba, S., Toyoda, Y., Furukawa, T., and Ishikawa, T., The impacts of posttranslational modifications and non-synonymous SNPs on the protein stability of human ABC transporter ABCG2 protein in culture cells. The FEBS-ABC2010 - 3rd FEBS Special Meeting on ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases., (March, 2010. Innsbruck)

Awards

Special ABC2010 Poster Recognition Award., The FEBS-ABC2010 - 3rd FEBS Special Meeting on ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases., (March, 2010. Innsbruck)

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