中部大学

中部大学

教員情報

呂 鋭 LU Rui

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職名 講師
所属 応用生物学部 食品栄養科学科
大学院 応用生物学研究科 応用生物学専攻
食環境創造研究センター
管理栄養実習センター
最終学歴 名古屋市立大学大学院医学研究科博士後期課程修了
学位 医学博士
所属学会・役職 日本生化学会
日本脂質生化学会
日本動脈硬化学会
専門分野 分子生物学、細胞生物学
研究テーマ 細胞コレステロール代謝の分子機構、HDL新生反応の制御
授業科目 生化学、生化学実験、食品分析学実験、基礎化学
公開連絡先 メールアドレス:lurui70@isc.chubu.ac.jp
電話番号:0568-51-9755

学術論文、評論

19. Rui Lu, Tomoe Tuboi, Kuniko Okumura-Noji, Noriyuki Iwamoto, and Shinji Yokoyama. Caveolin-1 facilitates Inter nalization and degradation of ABCA1 and probucol oxidative products interfere with this reaction to increase HDL biogenesis. Atherosclerosis. 2016 253: 54-60, 2016

18. Emi Yakushiji, Makoto Ayaori, Shunichi Takiguchi, Rui Lu, Shinji Yokoyama, Katsunori Ikewaki. Probucol Oxidized Spiroquinone and Di-phenoquinone, Promote Reverse Cholesterol Transport in Mice. Arterioscl. Thromb. Vasc. Biol. 36(4): 591-597, 2016

17. Yokoyama S, Okumura-Noji K, Lu R. Prevention of fatal hepatic complication in schistosomiasis by inhibition of CETP. J Biomed Res. 2015 May; 29(3): 176-88.

16. Ito J, Lu R, Nagayasu Y, Yokoyama S. Apolipoprotein A-I induces tubulin phosphorylation in association with cholesterol release in fetal rat astrocytes. Biochim Biophys Acta. 2014 Sep; 1841(9): 1234-40.

15. Okumura-Noji K, Miura Y, Lu R, Asai K, Ohta N, Brindley PJ, Yokoyama S. CD36-related protein in Schistosoma japonicum: candidate mediator of selective cholesteryl ester uptake from high-density lipoprotein for egg maturation. FASEB J. 2013 Mar; 27(3): 1236-44.

14. Yokoyama S, Arakawa R, Wu CA, Iwamoto N, Lu R, Tsujita M, Abe-Dohmae S. Calpain-mediated ABCA1 degradation: post-translational regulation of ABCA1 for HDL biogenesis. Biochim Biophys Acta. 2012 Mar; 1821(3): 547-51.

13. Ito J, Lu R, Nagayasu Y, Yokoyama S. Apolipoprotein A-I induces tubulin phosphorylation in association with cholesterol release in fetal rat astrocytes. Biochim Biophys Acta. 2014 Sep; 1841(9): 1234-40.

12. Yokoyama S, Arakawa R, Wu CA, Iwamoto N, Lu R, Tsujita M, Abe-Dohmae S. Calpain-mediated ABCA1 degradation: post-translational regulation of ABCA1 for HDL biogenesis. Biochim Biophys Acta. 2012 Mar; 1821(3): 547-51.

11. Iwamoto N, Lu R, Tanaka N, Abe-Dohmae S, Yokoyama S. Calmodulin interacts with ATP binding cassette transporter A1 to protect from calpain-mediated degradation and upregulates high-density lipoprotein generation. Arterioscler Thromb VascBiol. 2010 Jul; 30(7): 1446-52.

10. Arakawa R, Tsujita M, Iwamoto N, Ito-Ohsumi C, Lu R, Wu CA, Shimizu K, Aotsuka T, Kanazawa H, Abe-Dohmae S, Yokoyama S. Pharmacological inhibition of ABCA1 degradation increases HDL biogenesis and exhibits antiatherogenesis. J Lipid Res. 2009 Nov; 50(11): 2299-305.

9. Lu R, Ito J, Iwamoto N, Nishimaki-Mogami T, Yokoyama S. FGF-1 induces expression of LXRalpha and production of 25-hydroxycholesterol to upregulate the apoE gene in rat astrocytes. J Lipid Res. 2009 Jun; 50(6): 1156-64.

8. Iwamoto N, Abe-Dohmae S, Lu R, Yokoyama S. Involvement of protein kinase D in phosphorylation and increase of DNA binding of activator protein 2 alpha to downregulate ATP-binding cassette transporter A1. Arterioscler Thromb Vasc Biol. 2008 Dec; 28(12): 2282-7.

7. Lu R, Arakawa R, Ito-Osumi C, Iwamoto N, Yokoyama S. ApoA-I facilitates ABCA1 recycle/accumulation to cell surface by inhibiting its intracellular degradation and increases HDL generation. Arterioscler Thromb Vasc Biol. 2008 Oct; 28(10): 1820-4.

6. Ito J, Nagayasu Y, Okumura-Noji K, Lu R, Nishida T, Miura Y, Asai K, Kheirollah A, Nakaya S, Yokoyama S. Mechanism for FGF-1 to regulate biogenesis of apoE-HDL in astrocytes. J Lipid Res. 2007 Sep; 48(9): 2020-7.

5. Kheirollah A, Ito J, Nagayasu Y, Lu R, Yokoyama S. Cyclosporin A inhibits apolipoprotein A-I-induced early events in cellular cholesterol homeostasis in rat astrocytes. Neuropharmacology. 2006 Sep; 51(4): 693-700.

4. Ito J, Kheirollah A, Nagayasu Y, Lu R, Kato K, Yokoyama S. Apolipoprotein A-I increases association of cytosolic cholesterol and caveolin-1 with microtubule cytoskeletons in rat astrocytes. J Neurochem. 2006 May; 97(4): 1034-43.

3. Ito J, Nagayasu Y, Lu R, Kheirollah A, Hayashi M, Yokoyama S. Astrocytes produce and secrete FGF-1, which promotes the production of apoE-HDL in a manner of autocrine action. J Lipid Res. 2005 Apr; 46(4): 679-86.

2. Lu R, Niida H, Nakanishi M. Human SAD1 kinase is involved in UV-induced DNA damage checkpoint function. J Biol Chem. 2004 Jul 23; 279(30): 31164-70.

1. Li SF, Fujita F, Hirai M, Lu R, Niida H, Nakanishi M. Genomic structure and characterization of the promoter region of the human NAK gene. Gene. 2003 Jan 30; 304: 57-64.

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