中部大学実験動物教育研究センターを利用して得られた主な研究成果
2021年
An efficient i-GONAD method for creating and maintaining lethal mutant mice using an inversion balancer identified from the C3H/HeJJcl strain.
Iwata, S., Sasaki, T., Nagahara, M., & Iwamoto, T.
G3: Genes, Genomes, Genetics, 2021, 11(8), jkab194.
CREG1 improves diet‐induced obesity via uncoupling protein 1‐dependent manner in mice.
Endo, Y., Hashimoto, M., Kusudo, T., Okada, T., Takeuchi, T., Goto, A., & Yamashita, H. (2022).
Genes to Cells, 27(3), 202-213.
CREG1 administration stimulates BAT thermogenesis and improves diet-induced obesity in mice
Tatsuya Kusudo, Tadashi Okada, Michihiro Hashimoto, Tamaki Takeuchi, Yuki Endo, Ayumi Niwa, Hitoshi Yamashita
The Journal of Biochemistry, Volume 171, Issue 1, January 2022, Pages 63–73
Insulin potentiates the response to capsaicin in dorsal root ganglion neurons in vitro and muscle afferents ex vivo in normal healthy rodents.
Hori, A., Hotta, N., Fukazawa, A., Estrada, J. A., Katanosaka, K., Mizumura, K., … & Mizuno, M. (2022).
The Journal of Physiology, 600(3), 531-545.
Hyperthermal sarcomeric oscillations generated in warmed cardiomyocytes control amplitudes with chaotic properties while keeping cycles constant
Seine A. Shintani
Biochemical and Biophysical Research Communications, Volume 611, 2022, Pages 8-13, ISSN 0006-291X,
Hyperthermal sarcomeric oscillations generated in wa,rmed cardiomyocytes control amplitudes with chaotic properties while keeping cycles constant.
Shintani, S. A. (2022).
Biochemical and Biophysical Research Communications, 611, 8-13.
Changes in the structure and function of myofibrils during pressurization using a high-pressure microscope
Seine A Shintani.
J-STAGE Data 2021.
St8sia-deficiency in mice alters tumor environments of gliomas, leading to reduced disease severity.
Seine A. Shintani., Effects of high-pressure treatment on the structure and function of myofibrils., Biophysics and Physicobiology, 18, 85-95, 2021. Pu Zang, Yuki Ohkawa, Satoko Yamamoto, Hiroyuki Momota, Akira Kato, Kei Kaneko, Atsushi Natsume, Yesmin Farhana, Yuhsuke Ohmi, Tetsuya Okajima, Robiul H Bhuiyan, Toshihiko Wakabayashi, Keiko Furukawa, Koichi Furukawa.
Nagoya J Med Sci. 83, 535-549, 2021
2020年
Z-Isomers of lycopene exhibit greater liver accumulation than the all-E-isomer in mice.
Honda, M., Nakayama, Y., Nishikawa, S., & Tsuda, T.
Bioscience, biotechnology, and biochemistry, 2020, 84(2), 428-431.
Mechanism of contraction rhythm homeostasis for hyperthermal sarcomeric oscillations of neonatal cardiomyocytes.
Shintani, S. A., Washio, T., & Higuchi, H.
Scientific reports, 2020, 10(1), 1-12.
Forced expression of miR-143 and -145 in cardiomyocytes induces cardiomyopathy with a reductive redox shift.
Ogawa, K., Noda, A., Ueda, J., Ogata, T., Matsuyama, R., Nishizawa, Y., Qiao, S., Iwata, S., Ito, M., Fujihara, Y., Ichihara, M., Adachi, K., Takaoka, Y., Iwamoto, T.
Cellular & molecular biology letters, 2020, 25: 40-40
Peptides containing the MXXCW motif inhibit oncogenic RET kinase activity with a novel mechanism of action.
Takeda, K., Kawamoto, Y., Nagasaki, Y., Okuno, Y., Goto, Y., Iida, M., … & Kato, M.
American journal of cancer research, 2020, 10(1), 336
Artepillin C, a Key component of Brazilian propolis, induces thermogenesis in inguinal white adipose tissue of mice through a creatine-metabolism-related thermogenic pathway.
Nishikawa, S., Hydo, T., Aoyama, H., Miyata, R., Kumazawa, S., & Tsuda, T.
Journal of agricultural and food chemistry, 2020, 68(4), 1007-1014.
2019年
CREG1 stimulates brown adipocyte formation and ameliorates diet‐induced obesity in mice.
Hashimoto, M., Kusudo, T., Takeuchi, T., Kataoka, N., Mukai, T., & Yamashita, H.
The FASEB Journal, 2019, 33(7), 8069-8082.
A single administration of Neurotropin reduced the elongated immobility time in the forced swimming test of rats exposed to repeated cold stress.
Nasu, T., Kubo, A., Queme, L. F., & Mizumura, K.
Behavioural pharmacology, 2019, 30(7), 547-554.
In vitro and in vivo anti-herpes simplex virus activity of monogalactosyl diacylglyceride from Coccomyxa sp. KJ (IPOD FERM BP-22254), a green microalga.
Hayashi, K., Lee, J. B., Atsumi, K., Kanazashi, M., Shibayama, T., Okamoto, K., … & Hayashi, T.
PloS One, 2019, 14(7), e0219305.
Hydrogen gas improves left ventricular hypertrophy in Dahl rat of salt-sensitive hypertension.
Matsuoka, H., Miyata, S., Okumura, N., Watanabe, T., Hashimoto, K., Nagahara, M., … & Noda, A.
Clinical and Experimental Hypertension, 2019, 41(4), 307-311.
Co-administration of curcumin and artepillin C induces development of brown-like adipocytes in association with local norepinephrine production by alternatively activated macrophages in mice.
Nishikawa, S., Kamiya, M., Aoyama, H., Yoshimura, K., Miyata, R., Kumazawa, S., & Tsuda, T.
Journal of nutritional science and vitaminology, 2019, 65(4), 328-334.
Insulin potentiates the response to mechanical stimuli in small dorsal root ganglion neurons and thin fibre muscle afferents in vitro.
Hotta, N., Katanosaka, K., Mizumura, K., Iwamoto, G. A., Ishizawa, R., Kim, H. K., … & Mizuno, M.
The Journal of physiology, 2019, 597(20), 5049-5062
Simple and large-scale chromosomal engineering of mouse zygotes via in vitro and in vivo electroporation.
Iwata, S., Nakadai, H., Fukushi, D., Jose, M., Nagahara, M., & Iwamoto, T.
Scientific reports, 2019, 9.1: 1-8.doi: https://doi.org/10.1038/s41598-019-50900-y
Lowering barometric pressure induces neuronal activation in the superior vestibular nucleus in mice.
Sato, J., Inagaki, H., Kusui, M., Yokosuka, M., & Ushida, T.
PloS one, 2019, 14.1. doi: 10.1371/journal.pone.0211297
Depression-like behavior induced by repeated cold stress was reversed by Neurotropin in rats.
Nasu T, Kubo A, Queme L, Mizumura K.
Behav. Pharmacol. 2019.30(7):547-554
Inhibition of mast cell degranulation by melanin.
Kawamoto, Y., Kondo, H., Hasegawa, M., Kurimoto, C., Ishii, Y., Kato, C., … & Kawabe, M.
Biochemical pharmacology, 2019, 163: 178-193. doi: 10.1016/j.bcp.2019.02.015
Chondroitin sulfate attenuates acid-induced augmentation of the mechanical response in rat thin-fiber muscle afferents in vitro.
Hotta, N., Kubo, A., & Mizumura, K.
Applied Physiology 126.4 (2019): 1160-1170. doi: 10.1152/japplphysiol.00633.2018
PMID: 30763166
α-Monoglucosyl hesperidin but not hesperidin induces brown-like adipocyte formation and suppresses white adipose tissue accumulation in mice.
Nishikawa, S., Hyodo, T., Nagao, T., Nakanishi, A., Tandia, M., & Tsuda, T.
Journal of agricultural and food chemistry 67.7 (2019): 1948-1954. doi: 10.1021/acs.jafc.8b06647.
2018年
TRPV2 is required for mechanical nociception and the stretch-evoked response of primary sensory neurons.
Katanosaka, K., Takatsu, S., Mizumura, K., Naruse, K., & Katanosaka, Y.
Scientific reports 8.1 (2018): 1-10. doi: https://doi.org/10.1038/s41598-018-35049-4
Cerebellar role in predictive control of eye velocity initiation and termination.
Miki, S., Baker, R., & Hirata, Y.
Journal of Neuroscience, 2018, 38.48: 10371-10383. doi: 10.1523/JNEUROSCI.1375-18.2018
2017年
Testis-Specific Histone Variant H3t Gene Is Essential for Entry into Spermatogenesis.
Ueda J, Harada A, Urahama T, Machida S, Maehara K, Hada M, Makino Y, Nogami J, Horikoshi N, Osakabe A, Taguchi H, Tanaka H, Tachiwana H, Yao T, Yamada M, Iwamoto T, Isotani A, Ikawa M, Tachibana T, Okada Y, Kimura H, Ohkawa Y, Kurumizaka H, Yamagata K.
Cell Rep. 2017 Jan 17;18(3):593-600. doi: 10.1016/j.celrep.2016.12.065.
PMID: 28099840
2016年
Prevention of allergic rhinitis by ginger and the molecular basis of immunosuppression by 6-gingerol through T cell inactivation.
Kawamoto Y, Ueno Y, Nakahashi E, Obayashi M, Sugihara K, Qiao S, Iida M, Kumasaka MY, Yajima I, Goto Y, Ohgami N, Kato M, Takeda K.
J Nutr Biochem. 2016 Jan;27:112-22. doi: 10.1016/j.jnutbio.2015.08.025. Epub 2015 Sep 1.
PMID: 26403321
Transcription factor LSF (TFCP2) inhibits melanoma growth.
Goto Y, Yajima I, Kumasaka M, Ohgami N, Tanaka A, Tsuzuki T, Inoue Y, Fukushima S, Ihn H, Kyoya M, Ohashi H, Kawakami T, Bennett DC, Kato M.Oncotarget.
2016 Jan 19;7(3):2379-90. doi: 10.18632/oncotarget.6230.
PMID: 26506241
2015年
Possible abilities of dietary factors to prevent and treat diabetes via the stimulation of glucagon-like peptide-1 secretion.
Tsuda T.
Mol Nutr Food Res. 2015 Jul;59(7):1264-73. doi: 10.1002/mnfr.201400871. Epub 2015 Apr 7. Review.
PMID: 25707985
Deltex-3-like (DTX3L) stimulates metastasis of melanoma through FAK/PI3K/AKT but not MEK/ERK pathway.
Thang ND, Yajima I, Kumasaka MY, Iida M, Suzuki T, Kato M.
Oncotarget. 2015 Jun 10;6(16):14290-9.
PMID: 26033450
Arsenite-mediated promotion of anchorage-independent growth of HaCaT cells through placental growth factor.
Yajima I, Kumasaka MY, Ohnuma S, Ohgami N, Naito H, Shekhar HU, Omata Y, Kato M.
J Invest Dermatol. 2015 Apr;135(4):1147-56. doi: 10.1038/jid.2014.514. Epub 2014 Dec 10.
PMID: 25493652
Peripheral and spinal mechanisms of nociception in a rat reserpine-induced pain model.
Taguchi T, Katanosaka K, Yasui M, Hayashi K, Yamashita M, Wakatsuki K, Kiyama H, Yamanaka A, Mizumura K.Pain. 2015 Mar;156(3):415-27. doi: 10.1097/01.j.pain.0000460334.49525.5e.
PMID: 25599239
2014年
An actin-binding protein espin is a growth regulator for melanoma.
Yanagishita T, Yajima I, Kumasaka M, Iida M, Xiang L, Tamada Y, Matsumoto Y, Watanabe D, Kato M.
J Invest Dermatol. 2014 Dec;134(12):2996-9. doi: 10.1038/jid.2014.249. Epub 2014 Jun 17. No abstract available.
PMID: 24936833
2013年
10-Hydroxy-2-decenoic acid, a unique medium-chain fatty acid, activates 5′-AMP-activated protein kinase in L6 myotubes and mice.
Takikawa M, Kumagai A, Hirata H, Soga M, Yamashita Y, Ueda M, Ashida H, Tsuda T.
Mol Nutr Food Res. 2013 Oct;57(10):1794-802. doi: 10.1002/mnfr.201300041. Epub 2013 Jun 10.
PMID: 23754629
Upregulated glial cell line-derived neurotrophic factor through cyclooxygenase-2 activation in the muscle is required for mechanical hyperalgesia after exercise in rats.
Murase S, Terazawa E, Hirate K, Yamanaka H, Kanda H, Noguchi K, Ota H, Queme F, Taguchi T, Mizumura K.
J Physiol. 2013 Jun 15;591(12):3035-48. doi: 10.1113/jphysiol.2012.249235. Epub 2013 Apr 15.
PMID: 23587883
Reduced adult hippocampal neurogenesis and working memory deficits in the Dgcr8-deficient mouse model of 22q11.2 deletion-associated schizophrenia can be rescued by IGF2.
Ouchi Y, Banno Y, Shimizu Y, Ando S, Hasegawa H, Adachi K, Iwamoto T.
J Neurosci. 2013 May 29;33(22):9408-19. doi: 10.1523/JNEUROSCI.2700-12.2013.
PMID: 23719809
2012年
Genistein and daidzein, typical soy isoflavones, inhibit TNF-α-mediated downregulation of adiponectin expression via different mechanisms in 3T3-L1 adipocytes.
Yanagisawa M, Sugiya M, Iijima H, Nakagome I, Hirono S, Tsuda T.
Mol Nutr Food Res. 2012 Dec;56(12):1783-93. doi: 10.1002/mnfr.201200284. Epub 2012 Oct 29.
PMID: 23109410
Dietary anthocyanin-rich plants: biochemical basis and recent progress in health benefits studies.
Tsuda T.
Mol Nutr Food Res. 2012 Jan;56(1):159-70. doi: 10.1002/mnfr.201100526. Epub 2011 Nov 21. Review.
PMID: 22102523
2011年
Partial requirement of endothelin receptor B in spiral ganglion neurons for postnatal development of hearing.
Ida-Eto M, Ohgami N, Iida M, Yajima I, Kumasaka MY, Takaiwa K, Kimitsuki T, Sone M, Nakashima T, Tsuzuki T, Komune S, Yanagisawa M, Kato M.
J Biol Chem. 2011 Aug 26;286(34):29621-6. doi: 10.1074/jbc.M111.236802. Epub 2011 Jun 28.
PMID: 21715336
2010年
c-Ret-mediated hearing loss in mice with Hirschsprung disease.
Ohgami N, Ida-Eto M, Shimotake T, Sakashita N, Sone M, Nakashima T, Tabuchi K, Hoshino T, Shimada A, Tsuzuki T, Yamamoto M, Sobue G, Jijiwa M, Asai N, Hara A, Takahashi M, Kato M.
Proc Natl Acad Sci U S A. 2010 Jul 20;107(29):13051-6. doi: 10.1073/pnas.1004520107. Epub 2010 Jun 29.
PMID: 20616061
A novel mouse model for de novo Melanoma.
Kumasaka MY, Yajima I, Hossain K, Iida M, Tsuzuki T, Ohno T, Takahashi M, Yanagisawa M, Kato M.
Cancer Res. 2010 Jan 1;70(1):24-9. doi: 10.1158/0008-5472.CAN-09-2838.
PMID: 20048069
2008年
Evodiamine improves diet-induced obesity in a uncoupling protein-1-independent manner: involvement of antiadipogenic mechanism and extracellularly regulated kinase/mitogen-activated protein kinase signaling.
Wang T, Wang Y, Kontani Y, Kobayashi Y, Sato Y, Mori N, Yamashita H.
Endocrinology. 2008 Jan;149(1):358-66. Epub 2007 Sep 20.
PMID: 17884939
2007年
Protective effect of hyperpigmented skin on UV-mediated cutaneous cancer development.
Kato M, Ohgami N, Kawamoto Y, Tsuzuki T, Hossain K, Yanagishita T, Ohshima Y, Tsuboi H, Yamanoshita O, Matsumoto Y, Takahashi M, Nakashima I.
J Invest Dermatol. 2007 May;127(5):1244-9. Epub 2006 Dec 7.
PMID: 17159911